2H5E

Crystal structure of E.coli polypeptide release factor RF3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006415	biological_process	translational termination
A	0006449	biological_process	regulation of translational termination
A	0016149	molecular_function	translation release factor activity, codon specific
A	0016150	molecular_function	translation release factor activity, codon nonspecific
A	0019003	molecular_function	GDP binding
A	0097216	molecular_function	guanosine tetraphosphate binding
A	1990145	biological_process	maintenance of translational fidelity
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006415	biological_process	translational termination
B	0006449	biological_process	regulation of translational termination
B	0016149	molecular_function	translation release factor activity, codon specific
B	0016150	molecular_function	translation release factor activity, codon nonspecific
B	0019003	molecular_function	GDP binding
B	0097216	molecular_function	guanosine tetraphosphate binding
B	1990145	biological_process	maintenance of translational fidelity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GDP A 2567

Chain	Residue
A	ASP23
A	ASP145
A	ARG146
A	THR258
A	ALA259
A	LEU260
A	ALA24
A	GLY25
A	LYS26
A	THR27
A	THR28
A	HIS92
A	ASN142
A	LYS143

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP B 3567

Chain	Residue
A	GLY220
A	GLU221
B	ASP23
B	ALA24
B	GLY25
B	LYS26
B	THR27
B	THR28
B	HIS92
B	ASN142
B	LYS143
B	ASP145
B	THR258
B	ALA259
B	LEU260

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Functional Information from PROSITE/UniProt

site_id	PS00301
Number of Residues	16
Details	G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DWmemEKqRGISIttS

Chain	Residue	Details
A	ASP58-SER73

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	SER20
A	ASP88
A	ASN142
B	SER20
B	ASP88
B	ASN142

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