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2H44

Crystal structure of PDE5A1 in complex with icarisid II

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 501
ChainResidue
AHOH1
AHOH2
AHIS617
AHIS653
AASP654
AASP764

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 502
ChainResidue
AHOH4
AHIS613
AASP654
AHOH1
AHOH2
AHOH3

site_idAC3
Number of Residues24
DetailsBINDING SITE FOR RESIDUE 7CA A 301
ChainResidue
AHOH2
AHOH3
AHOH5
AHOH26
AHOH127
ATYR612
AHIS613
AASN661
ASER663
ATYR664
AILE665
ASER668
ALEU725
AASP764
ALEU765
AALA767
AILE768
AGLN775
AALA779
AVAL782
ALEU804
AMET816
AGLN817
APHE820

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY
ChainResidueDetails
AHIS653-TYR664

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS613

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF
ChainResidueDetails
AHIS617
AHIS653
AASP654
AASP764

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149
ChainResidueDetails
AGLN817

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PDB entries from 2025-06-11

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