2GX5
N-terminal GAF domain of transcriptional pleiotropic repressor CodY
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 501 |
| Chain | Residue |
| C | SER43 |
| C | ARG45 |
| C | LYS47 |
| C | HOH618 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 502 |
| Chain | Residue |
| A | PHE80 |
| A | GLY120 |
| A | ARG122 |
| D | SER12 |
| D | THR30 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 504 |
| Chain | Residue |
| B | SER43 |
| B | ARG45 |
| B | LYS47 |
| B | HOH592 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 505 |
| Chain | Residue |
| D | ASP68 |
| D | GLN70 |
| D | PHE71 |
| D | PRO72 |
| D | HOH534 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 506 |
| Chain | Residue |
| D | SER43 |
| D | ARG45 |
| D | LYS47 |
| D | LYS158 |
| D | HOH541 |
| D | HOH616 |
| D | HOH630 |
| D | HOH631 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 509 |
| Chain | Residue |
| A | SER43 |
| A | ARG45 |
| A | LYS47 |
| A | HOH551 |
| A | HOH553 |
| A | HOH614 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 510 |
| Chain | Residue |
| B | ALA17 |
| B | PRO21 |
| B | VAL22 |
| B | ASN23 |
| B | GLU26 |
| B | MET27 |
| B | GLU153 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 511 |
| Chain | Residue |
| B | ARG69 |
| C | HOH598 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 C 512 |
| Chain | Residue |
| C | GLY109 |
| C | GLN132 |
| D | ASP60 |
| D | ASP104 |
| D | GOL519 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE P6G C 513 |
| Chain | Residue |
| C | ARG61 |
| C | LYS64 |
| C | ASP104 |
| D | HOH618 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PCG C 514 |
| Chain | Residue |
| C | LYS25 |
| C | GLY50 |
| C | TYR51 |
| C | ARG69 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE A 515 |
| Chain | Residue |
| A | ASP90 |
| A | LEU110 |
| A | LEU131 |
| A | GLN132 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 516 |
| Chain | Residue |
| D | LYS20 |
| D | PRO21 |
| D | ASN23 |
| D | GLU26 |
| D | MET27 |
| D | GLU153 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 517 |
| Chain | Residue |
| C | ILE53 |
| C | GLN56 |
| C | ILE57 |
| C | ASN59 |
| C | MET62 |
| C | HOH558 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 518 |
| Chain | Residue |
| C | PRO115 |
| C | ILE116 |
| C | ILE117 |
| C | GLU144 |
| C | ALA147 |
| C | THR148 |
| C | HOH619 |
| D | ASN11 |
| D | GLN15 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 519 |
| Chain | Residue |
| C | PG4512 |
| D | ARG61 |
| D | LYS64 |
| D | HOH565 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 520 |
| Chain | Residue |
| A | MET13 |
| A | ALA16 |
| A | LYS20 |
| A | PRO21 |
| A | VAL22 |
| A | ASN23 |
| A | MET27 |
| A | GLU153 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 521 |
| Chain | Residue |
| D | ILE53 |
| D | GLN56 |
| D | ILE57 |
| D | HOH588 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 522 |
| Chain | Residue |
| D | HOH547 |
| D | VAL22 |
| D | ASN23 |
| D | PHE24 |
| D | LYS25 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 523 |
| Chain | Residue |
| B | ILE53 |
| B | GLN56 |
| B | ILE57 |
| B | LEU66 |
| B | HOH556 |
| site_id | CC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 524 |
| Chain | Residue |
| A | ILE9 |
| A | SER12 |
| A | MET13 |
| A | ALA16 |
| A | GLU26 |
| A | THR30 |
| D | GLU121 |
| D | ARG122 |
| D | HOH555 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 525 |
| Chain | Residue |
| A | GLN56 |
| A | ILE57 |
| A | ASN59 |
| A | LYS63 |
| A | HOH588 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 526 |
| Chain | Residue |
| B | ARG122 |
| C | SER12 |
| C | MET13 |
| C | GLU26 |
| C | THR30 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:16488888, ECO:0007744|PDB:2GX5 |
| Chain | Residue | Details |
| A | SER52 | |
| A | GLN70 | |
| B | SER52 | |
| B | GLN70 | |
| C | SER52 | |
| C | GLN70 | |
| D | SER52 | |
| D | GLN70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16488888, ECO:0007744|PDB:2HGV |
| Chain | Residue | Details |
| A | MET62 | |
| D | MET62 | |
| D | PRO99 | |
| D | GLU101 | |
| A | PRO99 | |
| A | GLU101 | |
| B | MET62 | |
| B | PRO99 | |
| B | GLU101 | |
| C | MET62 | |
| C | PRO99 | |
| C | GLU101 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28011634, ECO:0007744|PDB:5LOE |
| Chain | Residue | Details |
| A | ALA97 | |
| B | ALA97 | |
| C | ALA97 | |
| D | ALA97 |
