2GU5
E. coli methionine aminopeptidase in complex with NleP, 1: 1, di-metalated
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 265 |
| Chain | Residue |
| A | ASP108 |
| A | HIS171 |
| A | GLU204 |
| A | GLU235 |
| A | MN266 |
| A | NLP3808 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 266 |
| Chain | Residue |
| A | MN265 |
| A | NLP3808 |
| A | ASP97 |
| A | ASP108 |
| A | GLU235 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 265 |
| Chain | Residue |
| B | ASP108 |
| B | HIS171 |
| B | GLU204 |
| B | GLU235 |
| B | MN266 |
| B | NLP3808 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 266 |
| Chain | Residue |
| B | ASP97 |
| B | ASP108 |
| B | GLU235 |
| B | MN265 |
| B | NLP3808 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 300 |
| Chain | Residue |
| A | ASN74 |
| A | VAL76 |
| A | SER231 |
| A | HOH3829 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 300 |
| Chain | Residue |
| B | ASN74 |
| B | VAL76 |
| B | SER231 |
| B | HOH3817 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NLP A 3808 |
| Chain | Residue |
| A | TYR65 |
| A | CYS70 |
| A | HIS79 |
| A | ASP97 |
| A | THR99 |
| A | ASP108 |
| A | HIS171 |
| A | PHE177 |
| A | HIS178 |
| A | GLU204 |
| A | GLU235 |
| A | MN265 |
| A | MN266 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NLP B 3808 |
| Chain | Residue |
| B | TYR62 |
| B | CYS70 |
| B | HIS79 |
| B | ASP97 |
| B | THR99 |
| B | ASP108 |
| B | HIS171 |
| B | PHE177 |
| B | HIS178 |
| B | GLU204 |
| B | GLU235 |
| B | MN265 |
| B | MN266 |
| B | HOH3971 |
Functional Information from PROSITE/UniProt
| site_id | PS00680 |
| Number of Residues | 19 |
| Details | MAP_1 Methionine aminopeptidase subfamily 1 signature. YcGHGIGrgfHeepqVl.HY |
| Chain | Residue | Details |
| A | TYR168-TYR186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01974","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10555963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16769889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17120228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01974","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10387007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10555963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16769889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17120228","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18093325","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18785729","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10555963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16769889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17120228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a16 |
| Chain | Residue | Details |
| A | GLU204 | |
| A | GLN182 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a16 |
| Chain | Residue | Details |
| B | GLU204 | |
| B | GLN182 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a16 |
| Chain | Residue | Details |
| A | GLU204 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a16 |
| Chain | Residue | Details |
| B | GLU204 |
