2GT4

Crystal Structure of the Y103F mutant of the GDP-mannose mannosyl hydrolase in complex with GDP-mannose and MG+2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0008727	molecular_function	GDP-mannose mannosyl hydrolase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0047917	molecular_function	GDP-glucosidase activity
B	0000287	molecular_function	magnesium ion binding
B	0008727	molecular_function	GDP-mannose mannosyl hydrolase activity
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0030145	molecular_function	manganese ion binding
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0047917	molecular_function	GDP-glucosidase activity
C	0000287	molecular_function	magnesium ion binding
C	0008727	molecular_function	GDP-mannose mannosyl hydrolase activity
C	0009103	biological_process	lipopolysaccharide biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0030145	molecular_function	manganese ion binding
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0047917	molecular_function	GDP-glucosidase activity

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GrvqkdEtleaAFeRLTmAElG

Chain	Residue	Details
A	GLY51-GLY72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	15
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00941, ECO:0000269\|PubMed:15274914, ECO:0000269\|PubMed:16981689