2GT4
Crystal Structure of the Y103F mutant of the GDP-mannose mannosyl hydrolase in complex with GDP-mannose and MG+2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008727 | molecular_function | GDP-mannose mannosyl hydrolase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0047917 | molecular_function | GDP-glucosidase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008727 | molecular_function | GDP-mannose mannosyl hydrolase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0047917 | molecular_function | GDP-glucosidase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0008727 | molecular_function | GDP-mannose mannosyl hydrolase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0047917 | molecular_function | GDP-glucosidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GrvqkdEtleaAFeRLTmAElG |
| Chain | Residue | Details |
| A | GLY51-GLY72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 420 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"HAMAP-Rule","id":"MF_00941","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 63 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00941","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15274914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16981689","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Site: {"description":"Critical for catalysis"} |
| Chain | Residue | Details |
