2GT2

Structure of the E. coli GDP-mannose mannosyl hydrolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0008727	molecular_function	GDP-mannose mannosyl hydrolase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0047917	molecular_function	GDP-glucosidase activity
B	0000287	molecular_function	magnesium ion binding
B	0008727	molecular_function	GDP-mannose mannosyl hydrolase activity
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0030145	molecular_function	manganese ion binding
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0047917	molecular_function	GDP-glucosidase activity
C	0000287	molecular_function	magnesium ion binding
C	0008727	molecular_function	GDP-mannose mannosyl hydrolase activity
C	0009103	biological_process	lipopolysaccharide biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0030145	molecular_function	manganese ion binding
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0047917	molecular_function	GDP-glucosidase activity
D	0000287	molecular_function	magnesium ion binding
D	0008727	molecular_function	GDP-mannose mannosyl hydrolase activity
D	0009103	biological_process	lipopolysaccharide biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0030145	molecular_function	manganese ion binding
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0046872	molecular_function	metal ion binding
D	0047917	molecular_function	GDP-glucosidase activity

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GrvqkdEtleaAFeRLTmAElG

Chain	Residue	Details
A	GLY51-GLY72

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	PHE3
B	PHE3
C	PHE3
D	PHE3

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site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00941, ECO:0000269|PubMed:15274914, ECO:0000269|PubMed:16981689

Chain	Residue	Details
A	PHE9
B	GLN123
C	PHE9
C	ARG37
C	GLY50
C	GLU70
C	GLN123
D	PHE9
D	ARG37
D	GLY50
D	GLU70
A	ARG37
D	GLN123
A	GLY50
A	GLU70
A	GLN123
B	PHE9
B	ARG37
B	GLY50
B	GLU70

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Critical for catalysis

Chain	Residue	Details
A	HIS124
B	HIS124
C	HIS124
D	HIS124

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