Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GSM

Catalytic Core (Subunits I and II) of Cytochrome c oxidase from Rhodobacter sphaeroides

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006119	biological_process	oxidative phosphorylation
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006119	biological_process	oxidative phosphorylation
C	0009060	biological_process	aerobic respiration
C	0015990	biological_process	electron transport coupled proton transport
C	0016020	cellular_component	membrane
C	0020037	molecular_function	heme binding
C	0045277	cellular_component	respiratory chain complex IV
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
D	0004129	molecular_function	cytochrome-c oxidase activity
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0022900	biological_process	electron transport chain
D	0042773	biological_process	ATP synthesis coupled electron transport
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome
D	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DMU A 5001

Chain	Residue
A	TRP451
B	HOH5040
B	HOH5125
A	PHE510
A	TYR517
A	DMU5002
B	GLN142
B	TRP143
B	PRO164
B	HOH5017
B	HOH5033

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMU A 5002

Chain	Residue
A	TRP451
A	ALA506
A	DMU5001
A	HOH6627

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DMU B 5003

Chain	Residue
A	TRP371
B	PHE94
B	HIS96
B	ASN97
B	LEU100
B	TRP104
B	HOH5144
C	GLU86
D	SER173
D	PRO174
D	GLU177
D	HOH1151

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMU A 5004

Chain	Residue
A	MET443
A	SER444
A	HOH6557

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMU B 5011

Chain	Residue
B	PHE124
B	GLU128
B	HOH5146

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMU C 6002

Chain	Residue
C	TRP451
C	TRD6001

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMU D 6003

Chain	Residue
D	HIS96
D	ASN97

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMU C 6004

Chain	Residue
C	TRP20
C	MET443
C	SER444
C	ILE515
C	HOH1102

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMU C 6005

Chain	Residue
C	GLN61
C	PHE62
C	PRO82
C	HOH1152
C	HOH1164

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMU D 6011

Chain	Residue
D	PRO121
D	PHE124
D	ASN125
D	GLU128

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 3003

Chain	Residue
B	CYS252
B	GLU254
B	CYS256
B	HIS260
B	CU3004

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 3004

Chain	Residue
B	HIS217
B	CYS252
B	CYS256
B	MET263
B	CU3003

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 3005

Chain	Residue
A	HIS284
A	HIS333
A	HIS334
A	OH6501
A	HOH6506

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 3006

Chain	Residue
A	HIS411
A	ASP412
B	GLU254
B	HOH5042
B	HOH5048
B	HOH5055

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 3007

Chain	Residue
A	GLU54
A	ALA57
A	GLY59
A	GLN61
A	HOH6547
A	HOH6559

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 3008

Chain	Residue
B	GLU280
B	HIS283
B	HIS285
D	GLU152

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 3009

Chain	Residue
B	HIS96
B	GLU101
B	HOH5113
B	HOH5114

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU D 4003

Chain	Residue
D	CYS252
D	GLU254
D	CYS256
D	HIS260
D	CU4004

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU D 4004

Chain	Residue
D	HIS217
D	CYS252
D	CYS256
D	MET263
D	CU4003

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU C 4005

Chain	Residue
C	HOH1006
C	OH7501
C	HIS284
C	HIS333
C	HIS334

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 4006

Chain	Residue
C	HIS411
C	ASP412
D	GLU254
D	HOH1071
D	HOH1082
D	HOH1094

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 4007

Chain	Residue
C	GLU54
C	ALA57
C	GLY59
C	GLN61
C	HOH1085
C	HOH1107

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD D 4008

Chain	Residue
B	GLU152
D	GLU280
D	HIS283
D	HIS285

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD D 4009

Chain	Residue
D	HIS96
D	GLU101
D	HOH1196
D	HOH1197

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OH A 6501

Chain	Residue
A	HIS284
A	VAL287
A	HIS334
A	HEA2002
A	CU3005
A	HOH6506

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OH C 7501

Chain	Residue
C	HIS284
C	VAL287
C	HIS334
C	HOH1006
C	HEA3002
C	CU4005

site_id	CC9
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEA A 2001

Chain	Residue
A	LEU34
A	GLY38
A	THR48
A	MET51
A	ARG52
A	TRP95
A	ILE99
A	HIS102
A	MET106
A	GLY171
A	TRP172
A	TYR414
A	PHE420
A	HIS421
A	SER425
A	PHE468
A	GLN471
A	ARG481
A	ARG482
A	SER504
A	HOH6502
A	HOH6504
A	HOH6569

site_id	DC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE HEA A 2002

Chain	Residue
A	TRP172
A	TRP280
A	VAL287
A	TYR288
A	HIS333
A	HIS334
A	THR352
A	ILE355
A	THR359
A	GLY360
A	ILE363
A	GLY395
A	GLY398
A	ILE399
A	LEU401
A	SER402
A	ASP407
A	HIS411
A	VAL416
A	HIS419
A	PHE420
A	VAL423
A	MET424
A	ARG481
A	OH6501
A	HOH6506
A	HOH6515
A	HOH6524
A	HOH6533
A	HOH6553

site_id	DC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE HEA C 3001

Chain	Residue
C	LEU34
C	THR48
C	MET51
C	ARG52
C	TRP95
C	ILE99
C	HIS102
C	MET106
C	MET107
C	VAL111
C	GLY171
C	TRP172
C	TYR414
C	PHE420
C	HIS421
C	MET424
C	SER425
C	VAL429
C	PHE468
C	GLN471
C	ARG481
C	ARG482
C	SER504
C	PHE508
C	HOH1001
C	HOH1003
C	HOH1130

site_id	DC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE HEA C 3002

Chain	Residue
C	TRP172
C	TRP280
C	VAL287
C	TYR288
C	HIS333
C	HIS334
C	THR352
C	ILE355
C	THR359
C	GLY360
C	GLY395
C	GLY398
C	LEU401
C	SER402
C	ASP407
C	HIS411
C	VAL416
C	HIS419
C	PHE420
C	VAL423
C	MET424
C	ARG481
C	HOH1006
C	HOH1015
C	HOH1030
C	HOH1048
C	HOH1096
C	OH7501

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRD A 5005

Chain	Residue
A	MET56
A	HOH6585

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TRD A 5006

Chain	Residue
A	TRP81

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRD A 5007

Chain	Residue
A	ARG476
B	THR41

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TRD B 5008

Chain	Residue
A	MET350
A	VAL354
B	GLY116

site_id	DC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE TRD A 5010

Chain	Residue
B	HIS84

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TRD C 6001

Chain	Residue
C	TRP451
C	GLY513
C	DMU6002

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TRD C 6006

Chain	Residue
C	LEU80
C	TRP81
C	PRO82

site_id	EC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRD D 6007

Chain	Residue
C	ARG476
D	THR41

Functional Information from PROSITE/UniProt

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHswtvpafgvkqdavpgrlaqlwfraeregiffgq......CselCgisHayM

Chain	Residue	Details
B	VAL215-MET263

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiivlpafgivshviatfakkpifgylpmvyamvaigvlgfvvwa..HH

Chain	Residue	Details
A	TRP280-HIS334

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
B	PHE60-VAL80
A	PHE420-ILE440
A	LEU455-GLY475
A	LEU499-LEU519
C	ILE29-VAL49
C	VAL97-GLY117
C	LEU141-GLY161
C	LEU189-ILE209
C	LEU227-ALA247
C	ILE278-VAL298
C	ILE310-VAL330
B	TRP104-PHE124
C	PHE348-ALA368
C	MET381-LEU401
C	PHE420-ILE440
C	LEU455-GLY475
C	LEU499-LEU519
D	PHE60-VAL80
D	TRP104-PHE124
A	LEU227-ALA247
A	ILE278-VAL298
A	ILE310-VAL330
A	PHE348-ALA368
A	MET381-LEU401

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
B	HIS217
B	CYS252
B	CYS256
B	HIS260
D	HIS217
D	CYS252
D	CYS256
D	HIS260

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	HIS284
A	TYR288
A	HIS333
A	HIS334
C	HIS284
C	TYR288
C	HIS333
C	HIS334

site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250

Chain	Residue	Details
A	HIS284
A	TYR288
C	HIS284
C	TYR288

Catalytic Information from CSA

site_id	CSA1
Number of Residues	7
Details	Annotated By Reference To The Literature 1ar1

Chain	Residue	Details
A	HIS419
A	HIS421
A	ARG482
A	ARG481
A	PHE420
A	TYR288
A	HIS284

site_id	CSA2
Number of Residues	7
Details	Annotated By Reference To The Literature 1ar1

Chain	Residue	Details
C	HIS419
C	HIS421
C	ARG482
C	ARG481
C	PHE420
C	TYR288
C	HIS284

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ar1

Chain	Residue	Details
A	GLU286
A	LYS362

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ar1

Chain	Residue	Details
C	GLU286
C	LYS362

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)