2GRX
Crystal structure of TonB in complex with FhuA, E. coli outer membrane receptor for ferrichrome
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009279 | cellular_component | cell outer membrane |
| A | 0015343 | molecular_function | siderophore-iron transmembrane transporter activity |
| A | 0015891 | biological_process | siderophore transport |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0009279 | cellular_component | cell outer membrane |
| B | 0015343 | molecular_function | siderophore-iron transmembrane transporter activity |
| B | 0015891 | biological_process | siderophore transport |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0015891 | biological_process | siderophore transport |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0031992 | molecular_function | energy transducer activity |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0015891 | biological_process | siderophore transport |
| D | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| D | 0031992 | molecular_function | energy transducer activity |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS01156 |
| Number of Residues | 18 |
| Details | TONB_DEPENDENT_REC_2 TonB-dependent receptor (TBDR) proteins signature 2. GcfwGaERqVvATAtFrF |
| Chain | Residue | Details |
| A | GLY708-PHE725 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 412 |
| Details | TOPO_DOM: Periplasmic => ECO:0000305|PubMed:1885532 |
| Chain | Residue | Details |
| C | HIS33-GLN239 | |
| D | HIS33-GLN239 | |
| A | PRO223-LYS226 | |
| A | GLU289-THR293 | |
| A | LYS364-ASP371 | |
| A | GLN452-LYS455 | |
| A | LEU496-GLY500 | |
| A | VAL539-ARG543 | |
| A | PHE633-SER639 | |
| A | LEU677-ALA683 | |
| B | ALA1-GLU159 | |
| B | SER183-VAL189 | |
| B | PRO223-LYS226 | |
| B | GLU289-THR293 | |
| B | LYS364-ASP371 | |
| B | LEU589-ALA591 | |
| B | PHE633-SER639 | |
| B | LEU677-ALA683 | |
| A | PHE725 | |
| B | GLN452-LYS455 | |
| B | LEU496-GLY500 | |
| B | VAL539-ARG543 | |
| B | PHE725 | |
| A | LEU589-ALA591 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 354 |
| Details | TRANSMEM: Beta stranded |
| Chain | Residue | Details |
| A | PRO160-ALA168 | |
| A | PHE174-ASP182 | |
| A | TYR190-ALA198 | |
| A | TYR213-ARG222 | |
| A | THR227-PHE235 | |
| A | LYS280-HIS288 | |
| A | PHE294-PHE302 | |
| A | PHE355-SER363 | |
| A | HIS372-PHE380 | |
| A | THR443-ALA451 | |
| A | VAL456-TYR464 | |
| A | PHE487-TYR495 | |
| A | VAL501-GLU509 | |
| A | LYS530-TYR538 | |
| A | PRO544-TYR552 | |
| A | GLY580-ALA588 | |
| A | SER592-THR600 | |
| A | MET624-THR632 | |
| A | GLY640-ARG648 | |
| A | VAL668-ASP676 | |
| A | GLY684-ASN692 | |
| A | GLN716-ARG724 | |
| B | PRO160-ALA168 | |
| B | PHE174-ASP182 | |
| B | TYR190-ALA198 | |
| B | TYR213-ARG222 | |
| B | THR227-PHE235 | |
| B | LYS280-HIS288 | |
| B | PHE294-PHE302 | |
| B | PHE355-SER363 | |
| B | HIS372-PHE380 | |
| B | GLY580-ALA588 | |
| B | SER592-THR600 | |
| B | MET624-THR632 | |
| B | GLY640-ARG648 | |
| B | VAL668-ASP676 | |
| B | GLY684-ASN692 | |
| B | GLN716-ARG724 | |
| B | THR443-ALA451 | |
| B | VAL456-TYR464 | |
| B | PHE487-TYR495 | |
| B | VAL501-GLU509 | |
| B | LYS530-TYR538 | |
| B | PRO544-TYR552 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 578 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| A | GLY169-LEU173 | |
| A | ARG199-ARG212 | |
| A | ALA303-ASN354 | |
| A | MET381-SER431 | |
| A | ASP465-GLN486 | |
| A | SER510-GLY529 | |
| A | ASN553-ARG579 | |
| A | TYR601-HIS623 | |
| A | TYR649-THR667 | |
| A | ASN693-ARG715 | |
| B | GLY169-LEU173 | |
| B | ARG199-ARG212 | |
| B | GLN236-GLU279 | |
| B | ALA303-ASN354 | |
| B | ASN553-ARG579 | |
| B | TYR601-HIS623 | |
| B | TYR649-THR667 | |
| B | ASN693-ARG715 | |
| B | MET381-SER431 | |
| B | ASP465-GLN486 | |
| B | SER510-GLY529 | |
| A | GLN236-GLU279 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10850805, ECO:0000305|PubMed:9856937, ECO:0000305|PubMed:9865695 |
| Chain | Residue | Details |
| A | GLN100 | |
| A | TYR313 | |
| B | ARG81 | |
| B | GLN100 | |
| B | PHE115 | |
| B | TYR244 | |
| B | TYR313 | |
| A | ARG81 | |
| A | PHE115 | |
| A | TYR244 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:9856937 |
| Chain | Residue | Details |
| A | PHE391 | |
| A | ALA713 | |
| B | PHE391 | |
| B | ALA713 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Interaction with phage T5 RBP-pb5 => ECO:0000269|PubMed:36779755 |
| Chain | Residue | Details |
| A | PRO544 | |
| B | PRO544 |
