2GQV

High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0009410	biological_process	response to xenobiotic stimulus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17473013, ECO:0000269|PubMed:18052202, ECO:0007744|PDB:2P4T, ECO:0007744|PDB:2RK1, ECO:0007744|PDB:2RK2

Chain	Residue	Details
A	LYS32
A	VAL66

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18052202, ECO:0007744|PDB:2RK1

Chain	Residue	Details
A	ILE68

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1vie

Chain	Residue	Details
A	ILE68
A	LYS32
A	TYR69
A	GLN67

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 752

Chain	Residue	Details
A	LYS32	electrostatic stabiliser
A	GLN67	electrostatic stabiliser
A	ILE68	electrostatic stabiliser
A	TYR69	electrostatic stabiliser

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