2GQQ

Crystal Structure of E. coli Leucine-responsive regulatory protein (Lrp)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001216	molecular_function	DNA-binding transcription activator activity
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006524	biological_process	alanine catabolic process
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0043201	biological_process	response to L-leucine
A	0043565	molecular_function	sequence-specific DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001216	molecular_function	DNA-binding transcription activator activity
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006524	biological_process	alanine catabolic process
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0043201	biological_process	response to L-leucine
B	0043565	molecular_function	sequence-specific DNA binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001216	molecular_function	DNA-binding transcription activator activity
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006524	biological_process	alanine catabolic process
C	0032993	cellular_component	protein-DNA complex
C	0042802	molecular_function	identical protein binding
C	0043201	biological_process	response to L-leucine
C	0043565	molecular_function	sequence-specific DNA binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001216	molecular_function	DNA-binding transcription activator activity
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006524	biological_process	alanine catabolic process
D	0032993	cellular_component	protein-DNA complex
D	0042802	molecular_function	identical protein binding
D	0043201	biological_process	response to L-leucine
D	0043565	molecular_function	sequence-specific DNA binding
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS00519
Number of Residues	27
Details	HTH_ASNC_1 AsnC-type HTH domain signature. SnvELSkrVGLSptpcleRVrrLerqG

Chain	Residue	Details
A	SER30-GLY56

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00319

Chain	Residue	Details
A	VAL32-ARG51
B	VAL32-ARG51
C	VAL32-ARG51
D	VAL32-ARG51

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