2GMH

Structure of Porcine Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase in Complexed with Ubiquinone

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Functional Information from GO Data

ChainGOidnamespacecontents
A0031305cellular_componentintegral component of mitochondrial inner membrane
A0016020cellular_componentmembrane
A0005739cellular_componentmitochondrion
A0051539molecular_function4 iron, 4 sulfur cluster binding
A0009055molecular_functionelectron transfer activity
A0004174molecular_functionelectron-transferring-flavoprotein dehydrogenase activity
A0050660molecular_functionflavin adenine dinucleotide binding
A0051536molecular_functioniron-sulfur cluster binding
A0046872molecular_functionmetal ion binding
A0016491molecular_functionoxidoreductase activity
A0043783molecular_functionoxidoreductase activity, oxidizing metal ions with flavin as acceptor
A0048039molecular_functionubiquinone binding
A0022900biological_processelectron transport chain
A0022904biological_processrespiratory electron transport chain
A0006979biological_processresponse to oxidative stress
B0031305cellular_componentintegral component of mitochondrial inner membrane
B0016020cellular_componentmembrane
B0005739cellular_componentmitochondrion
B0051539molecular_function4 iron, 4 sulfur cluster binding
B0009055molecular_functionelectron transfer activity
B0004174molecular_functionelectron-transferring-flavoprotein dehydrogenase activity
B0050660molecular_functionflavin adenine dinucleotide binding
B0051536molecular_functioniron-sulfur cluster binding
B0046872molecular_functionmetal ion binding
B0016491molecular_functionoxidoreductase activity
B0043783molecular_functionoxidoreductase activity, oxidizing metal ions with flavin as acceptor
B0048039molecular_functionubiquinone binding
B0022900biological_processelectron transport chain
B0022904biological_processrespiratory electron transport chain
B0006979biological_processresponse to oxidative stress
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE BHG A 616
ChainResidue
ASER424
APHE441
APHE445
AMET448
APRO450
ATRP451

AC26BINDING SITE FOR RESIDUE BHG A 617
ChainResidue
ALEU128
APRO129
AGLY130
AHIS269
AILE428
ATRP443

AC31BINDING SITE FOR RESIDUE BHG B 618
ChainResidue
BPHE441

AC46BINDING SITE FOR RESIDUE NA A 1070
ChainResidue
AASN232
AHOH828
AHOH874
AHOH935
AHOH944
AHOH966

AC58BINDING SITE FOR RESIDUE SF4 A 610
ChainResidue
ALEU504
ACYS528
ACYS553
AVAL554
ACYS556
ALYS557
ACYS559
ATRP570

AC636BINDING SITE FOR RESIDUE FAD A 611
ChainResidue
AVAL41
AGLY42
AGLY44
APRO45
AALA46
AGLU71
ALYS72
AHIS79
ASER82
AGLY83
AALA84
ACYS85
AALA166
AALA167
AALA212
AGLU213
AGLY214
AHIS218
ALEU219
AARG331
AGLY353
ACYS354
AILE364
ALYS365
AGLY366
ATHR367
AHOH741
AHOH769
AHOH792
AHOH840
AHOH926
AHOH931
AHOH936
AHOH942
AHOH994
AHOH1043

AC713BINDING SITE FOR RESIDUE UQ5 A 612
ChainResidue
APHE114
AMET133
AHIS260
AVAL262
ATYR271
AGLY272
AGLY273
ASER274
AILE364
AGLY434
AMET435
ATHR438
AGLY439

AC812BINDING SITE FOR RESIDUE SF4 B 613
ChainResidue
BLEU504
BCYS528
BPRO529
BALA530
BVAL532
BTYR533
BCYS553
BVAL554
BCYS556
BLYS557
BCYS559
BTRP570

AC927BINDING SITE FOR RESIDUE FAD B 614
ChainResidue
BVAL41
BGLY42
BPRO45
BALA46
BGLU71
BLYS72
BHIS79
BSER82
BGLY83
BALA84
BCYS85
BALA167
BGLU213
BGLY214
BHIS218
BPHE275
BTYR277
BARG331
BGLY353
BCYS354
BILE364
BLYS365
BGLY366
BTHR367
BVAL572
BHOH859
BHOH1013

BC113BINDING SITE FOR RESIDUE UQ5 B 615
ChainResidue
BPHE114
BMET133
BHIS260
BTHR261
BVAL262
BGLY272
BGLY273
BSER274
BILE364
BGLY434
BMET435
BTHR438
BGLY439

BC25BINDING SITE FOR RESIDUE EDO A 619
ChainResidue
AGLN480
AGLU497
AGLU574
AGLY577
AHOH811

BC34BINDING SITE FOR RESIDUE EDO B 620
ChainResidue
BPRO129
BGLY130
BARG268
BTRP443

BC44BINDING SITE FOR RESIDUE EDO A 621
ChainResidue
AVAL489
AALA490
ATHR494
AHOH857

BC56BINDING SITE FOR RESIDUE EDO A 622
ChainResidue
AHIS12
ATYR13
AALA168
AHIS218
AVAL571
AVAL572

BC68BINDING SITE FOR RESIDUE EDO A 623
ChainResidue
AILE9
ATHR10
ATHR11
AHIS12
AALA502
ALEU504
ATHR505
AILE548

BC710BINDING SITE FOR RESIDUE EDO A 624
ChainResidue
ALYS324
AARG325
APHE483
AGLY493
AASN495
AALA580
AHOH767
AHOH905
AHOH919
AHOH993

BC81BINDING SITE FOR RESIDUE EDO A 625
ChainResidue
AARG268

BC92BINDING SITE FOR RESIDUE EDO A 626
ChainResidue
AGLN525
AHOH934

CC13BINDING SITE FOR RESIDUE EDO A 627
ChainResidue
AASN280
AGLY282
AHOH1050

CC22BINDING SITE FOR RESIDUE EDO A 628
ChainResidue
APHE32
AALA33

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
EDO_2gmh_A_623101,2-ETHANEDIOL binding site
ChainResidueligand
AILE9-HIS12EDO: 1,2-ETHANEDIOL
APRO501-ALA502EDO: 1,2-ETHANEDIOL
ALEU504-LEU506EDO: 1,2-ETHANEDIOL
AILE548EDO: 1,2-ETHANEDIOL

EDO_2gmh_A_622121,2-ETHANEDIOL binding site
ChainResidueligand
AHIS12-THR14EDO: 1,2-ETHANEDIOL
AALA167-GLU169EDO: 1,2-ETHANEDIOL
AASN184EDO: 1,2-ETHANEDIOL
AHIS218-LEU219EDO: 1,2-ETHANEDIOL
AVAL571-PRO573EDO: 1,2-ETHANEDIOL

EDO_2gmh_A_62831,2-ETHANEDIOL binding site
ChainResidueligand
AARG31-ALA33EDO: 1,2-ETHANEDIOL

FAD_2gmh_A_61150FLAVIN-ADENINE DINUCLEOTIDE binding site
ChainResidueligand
AVAL41-GLY47FAD: FLAVIN-ADENINE DINUCLEOTIDE
AVAL70-ALA73FAD: FLAVIN-ADENINE DINUCLEOTIDE
AHIS79-LEU86FAD: FLAVIN-ADENINE DINUCLEOTIDE
ALEU143FAD: FLAVIN-ADENINE DINUCLEOTIDE
ATYR165-ALA167FAD: FLAVIN-ADENINE DINUCLEOTIDE
AALA212-CYS215FAD: FLAVIN-ADENINE DINUCLEOTIDE
AHIS218-LEU219FAD: FLAVIN-ADENINE DINUCLEOTIDE
AGLY241-LYS243FAD: FLAVIN-ADENINE DINUCLEOTIDE
APHE275FAD: FLAVIN-ADENINE DINUCLEOTIDE
ATYR277FAD: FLAVIN-ADENINE DINUCLEOTIDE
AVAL291FAD: FLAVIN-ADENINE DINUCLEOTIDE
AARG331-LEU333FAD: FLAVIN-ADENINE DINUCLEOTIDE
AILE352-SER355FAD: FLAVIN-ADENINE DINUCLEOTIDE
AMET359FAD: FLAVIN-ADENINE DINUCLEOTIDE
AILE364-HIS368FAD: FLAVIN-ADENINE DINUCLEOTIDE
AALA370FAD: FLAVIN-ADENINE DINUCLEOTIDE
AVAL572FAD: FLAVIN-ADENINE DINUCLEOTIDE

UQ5_2gmh_A_612262,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE binding site
ChainResidueligand
APHE114UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AVAL125UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
ALEU131UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AMET133UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AHIS260-VAL262UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
ATYR271-PHE275UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AVAL291UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
APRO362UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AILE364UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AILE421UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
ACYS425UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AVAL431UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
AGLY434-ILE436UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
ATHR438-ILE440UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
ATRP443-ILE444UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE

BHG_2gmh_A_61772-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL binding site
ChainResidueligand
ALEU128-LEU131BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
ATRP443-ILE444BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
AARG446BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL

EDO_2gmh_A_62741,2-ETHANEDIOL binding site
ChainResidueligand
ATRP253EDO: 1,2-ETHANEDIOL
AASN280-GLY282EDO: 1,2-ETHANEDIOL

EDO_2gmh_A_62531,2-ETHANEDIOL binding site
ChainResidueligand
AASP267-ARG268EDO: 1,2-ETHANEDIOL
ATYR432EDO: 1,2-ETHANEDIOL

BHG_2gmh_A_61662-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL binding site
ChainResidueligand
ASER424BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
AGLY427BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
ATYR437BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
APHE441BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
ATRP451BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
ALEU453BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL

EDO_2gmh_A_62181,2-ETHANEDIOL binding site
ChainResidueligand
ALEU486EDO: 1,2-ETHANEDIOL
AVAL489-ALA490EDO: 1,2-ETHANEDIOL
ASER492-ASN495EDO: 1,2-ETHANEDIOL
AASN552EDO: 1,2-ETHANEDIOL

EDO_2gmh_A_62441,2-ETHANEDIOL binding site
ChainResidueligand
AGLY493-ASN495EDO: 1,2-ETHANEDIOL
AALA580EDO: 1,2-ETHANEDIOL

EDO_2gmh_A_61981,2-ETHANEDIOL binding site
ChainResidueligand
AASN495-GLU497EDO: 1,2-ETHANEDIOL
AGLN500EDO: 1,2-ETHANEDIOL
AGLU574-GLY577EDO: 1,2-ETHANEDIOL

SF4_2gmh_A_61015IRON/SULFUR CLUSTER binding site
ChainResidueligand
ALEU504SF4: IRON/SULFUR CLUSTER
APHE527-ALA530SF4: IRON/SULFUR CLUSTER
AVAL532-TYR533SF4: IRON/SULFUR CLUSTER
ACYS553-CYS559SF4: IRON/SULFUR CLUSTER
ATRP570SF4: IRON/SULFUR CLUSTER

EDO_2gmh_A_62651,2-ETHANEDIOL binding site
ChainResidueligand
ALEU517EDO: 1,2-ETHANEDIOL
AASP521EDO: 1,2-ETHANEDIOL
AGLN525EDO: 1,2-ETHANEDIOL
APHE535EDO: 1,2-ETHANEDIOL
APHE544EDO: 1,2-ETHANEDIOL

FAD_2gmh_B_61449FLAVIN-ADENINE DINUCLEOTIDE binding site
ChainResidueligand
BVAL41-GLY47FAD: FLAVIN-ADENINE DINUCLEOTIDE
BVAL70-ALA73FAD: FLAVIN-ADENINE DINUCLEOTIDE
BHIS79-LEU86FAD: FLAVIN-ADENINE DINUCLEOTIDE
BLEU143FAD: FLAVIN-ADENINE DINUCLEOTIDE
BTYR165-ALA167FAD: FLAVIN-ADENINE DINUCLEOTIDE
BALA212-CYS215FAD: FLAVIN-ADENINE DINUCLEOTIDE
BHIS218-LEU219FAD: FLAVIN-ADENINE DINUCLEOTIDE
BGLY241FAD: FLAVIN-ADENINE DINUCLEOTIDE
BPHE275FAD: FLAVIN-ADENINE DINUCLEOTIDE
BTYR277FAD: FLAVIN-ADENINE DINUCLEOTIDE
BVAL291FAD: FLAVIN-ADENINE DINUCLEOTIDE
BARG331-LEU333FAD: FLAVIN-ADENINE DINUCLEOTIDE
BILE352-SER355FAD: FLAVIN-ADENINE DINUCLEOTIDE
BMET359FAD: FLAVIN-ADENINE DINUCLEOTIDE
BILE364-HIS368FAD: FLAVIN-ADENINE DINUCLEOTIDE
BALA370FAD: FLAVIN-ADENINE DINUCLEOTIDE
BLYS557FAD: FLAVIN-ADENINE DINUCLEOTIDE
BVAL572FAD: FLAVIN-ADENINE DINUCLEOTIDE

UQ5_2gmh_B_615252,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE binding site
ChainResidueligand
BPHE114UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BVAL125UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BLEU131UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BMET133UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BHIS260-VAL262UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BTYR271-SER274UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BPRO362UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BILE364UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BILE421-ARG422UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BCYS425UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BVAL431UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BGLY434-ILE436UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BTHR438-ILE440UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE
BTRP443-ILE444UQ5: 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE

EDO_2gmh_B_62051,2-ETHANEDIOL binding site
ChainResidueligand
BLEU128-GLY130EDO: 1,2-ETHANEDIOL
BTRP443EDO: 1,2-ETHANEDIOL
BARG446EDO: 1,2-ETHANEDIOL

BHG_2gmh_B_61832-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL binding site
ChainResidueligand
BILE440-PHE441BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
BPHE445BHG: 2-HEXYLOXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL

SF4_2gmh_B_61315IRON/SULFUR CLUSTER binding site
ChainResidueligand
BLEU504SF4: IRON/SULFUR CLUSTER
BPHE527-ALA530SF4: IRON/SULFUR CLUSTER
BVAL532-TYR533SF4: IRON/SULFUR CLUSTER
BCYS553-CYS559SF4: IRON/SULFUR CLUSTER
BTRP570SF4: IRON/SULFUR CLUSTER

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI14Iron-sulfur (4Fe-4S)
ChainResidueDetails
ACYS528
ACYS553
ACYS556
ACYS559

SWS_FT_FI21Ubiquinone; via carbonyl oxygen.
ChainResidueDetails
AGLY272

SWS_FT_FI31Ubiquinone; via amide nitrogen.
ChainResidueDetails
AGLY273

SWS_FT_FI46FAD.
ChainResidueDetails
AGLY42-GLY47

SWS_FT_FI54Iron-sulfur (4Fe-4S)
ChainResidueDetails
BCYS528
BCYS553
BCYS556
BCYS559

SWS_FT_FI61Ubiquinone; via carbonyl oxygen.
ChainResidueDetails
BGLY272

SWS_FT_FI71Ubiquinone; via amide nitrogen.
ChainResidueDetails
BGLY273

SWS_FT_FI86FAD.
ChainResidueDetails
BGLY42-GLY47

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
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