2GL7
Crystal Structure of a beta-catenin/BCL9/Tcf4 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007155 | biological_process | cell adhesion |
| A | 0045296 | molecular_function | cadherin binding |
| B | 0016055 | biological_process | Wnt signaling pathway |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0008013 | molecular_function | beta-catenin binding |
| C | 0060070 | biological_process | canonical Wnt signaling pathway |
| D | 0007155 | biological_process | cell adhesion |
| D | 0045296 | molecular_function | cadherin binding |
| E | 0016055 | biological_process | Wnt signaling pathway |
| F | 0003713 | molecular_function | transcription coactivator activity |
| F | 0008013 | molecular_function | beta-catenin binding |
| F | 0060070 | biological_process | canonical Wnt signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9D219 |
| Chain | Residue | Details |
| C | SER352 | |
| F | SER352 | |
| E | LYS22 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CDK5 => ECO:0000269|PubMed:17009320, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER191 | |
| D | SER191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CDK5 => ECO:0000269|PubMed:17009320 |
| Chain | Residue | Details |
| A | SER246 | |
| D | SER246 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by PTK6 => ECO:0000269|PubMed:20026641 |
| Chain | Residue | Details |
| A | TYR331 | |
| D | TYR331 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by SRC and PTK6 => ECO:0000269|PubMed:22056988, ECO:0000305|PubMed:20026641 |
| Chain | Residue | Details |
| A | TYR333 | |
| D | TYR333 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER552 | |
| D | SER552 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336 |
| Chain | Residue | Details |
| A | THR556 | |
| D | THR556 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q02248 |
| Chain | Residue | Details |
| A | CYS619 | |
| D | CYS619 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER675 | |
| D | SER675 |
