2GL7
Crystal Structure of a beta-catenin/BCL9/Tcf4 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0007155 | biological_process | cell adhesion |
| A | 0045296 | molecular_function | cadherin binding |
| B | 0016055 | biological_process | Wnt signaling pathway |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0008013 | molecular_function | beta-catenin binding |
| C | 0060070 | biological_process | canonical Wnt signaling pathway |
| D | 0007155 | biological_process | cell adhesion |
| D | 0045296 | molecular_function | cadherin binding |
| E | 0016055 | biological_process | Wnt signaling pathway |
| F | 0003713 | molecular_function | transcription coactivator activity |
| F | 0008013 | molecular_function | beta-catenin binding |
| F | 0060070 | biological_process | canonical Wnt signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"ARM 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 56 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"ARM 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 44 |
| Details | Region: {"description":"Interaction with BCL9","evidences":[{"source":"PubMed","id":"17052462","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by FYN and PTK6","evidences":[{"source":"PubMed","id":"12640114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20026641","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK5","evidences":[{"source":"PubMed","id":"17009320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK5","evidences":[{"source":"PubMed","id":"17009320","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by PTK6","evidences":[{"source":"PubMed","id":"20026641","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC and PTK6","evidences":[{"source":"PubMed","id":"22056988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20026641","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q02248","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 16 |
| Details | Region: {"description":"Interaction with CTNNB1","evidences":[{"source":"PubMed","id":"17052462","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9D219","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
