2GKL

Crystal structure of the zinc carbapenemase CPHA in complex with the inhibitor pyridine-2,4-dicarboxylate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	PD22
A	ASP120
A	CYS221
A	HIS263

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PD2 A 2

Chain	Residue
A	GLY232
A	ASN233
A	HIS263
A	ZN401
A	HOH402
A	HOH407
A	HOH531
A	VAL67
A	ASP120
A	HIS196
A	CYS221
A	LYS224

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 3

Chain	Residue
A	ARG188
A	PHE190
A	TYR204
A	MET252
A	LEU254
A	HOH491

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 4

Chain	Residue
A	HIS176
A	ASP177
A	GLY178
A	ASP179

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 5

Chain	Residue
A	LEU267
A	HIS289
A	GLY290
A	GLU292
A	HOH515
A	HOH568

---

Functional Information from PROSITE/UniProt

site_id	PS00743
Number of Residues	20
Details	BETA_LACTAMASE_B_1 Beta-lactamases class B signature 1. InTNyHTDraGGnaywksi.G

Chain	Residue	Details
A	ILE113-GLY133

---

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PdeqVLyGnCILK

Chain	Residue	Details
A	PRO209-LYS224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17307979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563261","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19651913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20527888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563261","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20527888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17307979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20527888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15588826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17307979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18563261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120
A	ASN233

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 2bmi

Chain	Residue	Details
A	ASP120

---