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2GJ6

The complex between TCR A6 and human Class I MHC HLA-A2 with the modified HTLV-1 TAX (Y5K-4-[3-Indolyl]-butyric acid) peptide

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 E 414
ChainResidue
BLYS94
ESER68
EARG69
ESER70
EPRO76
EARG78
EHOH417

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 E 415
ChainResidue
EGLN22
EARG78
BGLU77
ETHR20

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 416
ChainResidue
ATRP133
ATHR134
AALA135
AGLN141
ALYS144
EGLN57

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B 417
ChainResidue
BARG12
BHIS13

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 418
ChainResidue
AGLY16
AARG17
AGLY18
BARG3

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 3IB C 10
ChainResidue
AGLN155
CLYS5
DSER31
DTYR50
DTHR98
DASP99
EARG95
EPRO96
EGLY97
EPRO103

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 401
ChainResidue
BASP34
BASN83
BHIS84
BVAL85

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 402
ChainResidue
AALA41
AGLN87
ASER88
AHOH424
AHOH450

site_idAC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 403
ChainResidue
AARG21
AILE23
BSER33
BHIS51
BSER52
BASP53
BLEU54
BLEU64

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL E 404
ChainResidue
EPRO8
ELYS9
EPHE10

site_idBC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL C 405
ChainResidue
ALYS146
CVAL9

site_idBC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 406
ChainResidue
BSER88
DTRP101
ETYR48

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL B 407
ChainResidue
BGLY18
BLYS19
BSER20

site_idBC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 408
ChainResidue
BILE7
BGLN8
BVAL9
BVAL93
BLYS94
BTRP95
BASP96
BMET99

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 409
ChainResidue
BLYS41
BPHE70
BTHR71
BTYR78

site_idBC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL E 410
ChainResidue
EVAL157
ELEU159

site_idBC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 411
ChainResidue
BGLU77
BHOH429
EASN66
EVAL67
EARG78

site_idBC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 412
ChainResidue
AASP137
AMET138
AALA139
BGLU36
BVAL37
BASP38
BARG45

site_idCC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 413
ChainResidue
AARG6
APHE8
ATYR27
AASP29
AASP30

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
ATYR257-HIS263
BTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
EASN186
DASN183
ATYR84
ATHR143
ALYS146
ATYR171

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
DASN194
ATYR159

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443
ChainResidueDetails
BLYS19
BLYS41
BLYS48
BLYS58
BLYS91
BLYS94

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN86

223532

PDB entries from 2024-08-07

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