2GIV

Human MYST histone acetyltransferase 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS37
A	CYS40
A	HIS53
A	CYS57

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 502

Chain	Residue
A	ASP17
A	HOH507
A	HOH522
A	HOH529

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site_id	AC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE ACO A 500

Chain	Residue
A	PHE97
A	LEU98
A	ALA142
A	CYS143
A	ILE144
A	LEU145
A	THR146
A	GLN151
A	ARG152
A	ARG153
A	GLY154
A	GLY156
A	LYS157
A	GLU177
A	LEU180
A	SER181
A	LEU183
A	LEU186
A	SER187
A	SER190
A	HOH503
A	HOH515
A	HOH525
A	HOH536
A	HOH623
A	HOH659
A	HOH660
A	TRP19

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063, ECO:0000269|PubMed:22020126

Chain	Residue	Details
A	LEU34-TRP59

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000303|PubMed:21217699, ECO:0000303|PubMed:22020126, ECO:0000305

Chain	Residue	Details
A	GLU177

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.23

Chain	Residue	Details
A	ILE144
A	GLN151
A	SER181
A	SER190
A	LYS259

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|Ref.23

Chain	Residue	Details
A	ALY101

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER175

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1mj9

Chain	Residue	Details
A	CYS143
A	GLU177

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