2GIV
Human MYST histone acetyltransferase 1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS37 |
| A | CYS40 |
| A | HIS53 |
| A | CYS57 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 502 |
| Chain | Residue |
| A | ASP17 |
| A | HOH507 |
| A | HOH522 |
| A | HOH529 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE ACO A 500 |
| Chain | Residue |
| A | PHE97 |
| A | LEU98 |
| A | ALA142 |
| A | CYS143 |
| A | ILE144 |
| A | LEU145 |
| A | THR146 |
| A | GLN151 |
| A | ARG152 |
| A | ARG153 |
| A | GLY154 |
| A | GLY156 |
| A | LYS157 |
| A | GLU177 |
| A | LEU180 |
| A | SER181 |
| A | LEU183 |
| A | LEU186 |
| A | SER187 |
| A | SER190 |
| A | HOH503 |
| A | HOH515 |
| A | HOH525 |
| A | HOH536 |
| A | HOH623 |
| A | HOH659 |
| A | HOH660 |
| A | TRP19 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | ZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063, ECO:0000269|PubMed:22020126 |
| Chain | Residue | Details |
| A | LEU34-TRP59 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:21217699, ECO:0000305|PubMed:27768893, ECO:0000305|PubMed:33657400 |
| Chain | Residue | Details |
| A | GLU177 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:27382063, ECO:0000269|PubMed:29321206, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV, ECO:0007744|PDB:2PQ8, ECO:0007744|PDB:2Y0M, ECO:0007744|PDB:3QAH, ECO:0007744|PDB:3TOA, ECO:0007744|PDB:3TOB, ECO:0007744|PDB:4DNC, ECO:0007744|PDB:5J8C, ECO:0007744|PDB:5J8F, ECO:0007744|PDB:5WCI |
| Chain | Residue | Details |
| A | CYS37 | |
| A | CYS40 | |
| A | HIS53 | |
| A | CYS57 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29321206, ECO:0007744|PDB:5WCI |
| Chain | Residue | Details |
| A | ILE144 | |
| A | THR146 | |
| A | ARG152 | |
| A | GLY156 | |
| A | LYS157 | |
| A | SER181 | |
| A | SER190 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV, ECO:0007744|PDB:2Y0M |
| Chain | Residue | Details |
| A | ARG153 | |
| A | GLY154 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21217699, ECO:0007744|PDB:2Y0M |
| Chain | Residue | Details |
| A | TYR235 | |
| A | LYS259 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|PubMed:22918831, ECO:0000269|PubMed:27382063, ECO:0000269|Ref.33, ECO:0007744|PDB:2GIV |
| Chain | Residue | Details |
| A | ALY101 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER175 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mj9 |
| Chain | Residue | Details |
| A | CYS143 | |
| A | GLU177 |
