2GHQ

CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016791	molecular_function	phosphatase activity
B	0016791	molecular_function	phosphatase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 151

Chain	Residue
A	ASN96
A	ASP98
A	ASN207
C	SEP174

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 257

Chain	Residue
B	ASN96
B	ASP98
B	ASN207
D	SEP174

---

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
C	TYR170-SER176

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	316
Details	Domain: {"description":"FCP1 homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00336","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"15304220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17157258","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15304220","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15304220","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"15304220","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"26566685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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