2GEK
Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium smegmatis in complex with GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004377 | molecular_function | GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0009247 | biological_process | glycolipid biosynthetic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0043750 | molecular_function | phosphatidylinositol alpha-mannosyltransferase activity |
| A | 0046488 | biological_process | phosphatidylinositol metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GDP A 2567 |
| Chain | Residue |
| A | PRO14 |
| A | LYS256 |
| A | ILE278 |
| A | VAL279 |
| A | GLU282 |
| A | GLY15 |
| A | GLY16 |
| A | LEU194 |
| A | LYS202 |
| A | GLN250 |
| A | VAL251 |
| A | ASP252 |
| A | ASP253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:17510062 |
| Chain | Residue | Details |
| A | TYR9 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17510062, ECO:0000269|PubMed:19520856 |
| Chain | Residue | Details |
| A | GLY16 | |
| A | VAL251 | |
| A | LYS256 | |
| A | GLU282 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19520856 |
| Chain | Residue | Details |
| A | GLN18 | |
| A | TYR62 | |
| A | ARG68 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17510062, ECO:0000305|PubMed:19520856 |
| Chain | Residue | Details |
| A | ARG196 | |
| A | ARG201 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17510062 |
| Chain | Residue | Details |
| A | GLU274 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for catalytic activity => ECO:0000269|PubMed:17510062 |
| Chain | Residue | Details |
| A | HIS118 |
