2GCO
Crystal structure of the human RhoC-GppNHp complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0016477 | biological_process | cell migration |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0031334 | biological_process | positive regulation of protein-containing complex assembly |
| A | 0032154 | cellular_component | cleavage furrow |
| A | 0032420 | cellular_component | stereocilium |
| A | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0043297 | biological_process | apical junction assembly |
| A | 0044319 | biological_process | wound healing, spreading of cells |
| A | 0051496 | biological_process | positive regulation of stress fiber assembly |
| A | 0060193 | biological_process | positive regulation of lipase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1902766 | biological_process | skeletal muscle satellite cell migration |
| B | 0000281 | biological_process | mitotic cytokinesis |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007015 | biological_process | actin filament organization |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0016477 | biological_process | cell migration |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0030335 | biological_process | positive regulation of cell migration |
| B | 0031334 | biological_process | positive regulation of protein-containing complex assembly |
| B | 0032154 | cellular_component | cleavage furrow |
| B | 0032420 | cellular_component | stereocilium |
| B | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0043297 | biological_process | apical junction assembly |
| B | 0044319 | biological_process | wound healing, spreading of cells |
| B | 0051496 | biological_process | positive regulation of stress fiber assembly |
| B | 0060193 | biological_process | positive regulation of lipase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1902766 | biological_process | skeletal muscle satellite cell migration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | THR19 |
| A | THR37 |
| A | GNP1001 |
| A | HOH1049 |
| A | HOH1080 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1004 |
| Chain | Residue |
| B | HOH1059 |
| B | THR19 |
| B | THR37 |
| B | GNP1003 |
| B | HOH1027 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE GNP A 1001 |
| Chain | Residue |
| A | GLY14 |
| A | ALA15 |
| A | CYS16 |
| A | GLY17 |
| A | LYS18 |
| A | THR19 |
| A | CYS20 |
| A | PHE30 |
| A | VAL35 |
| A | THR37 |
| A | GLY62 |
| A | LYS118 |
| A | ASP120 |
| A | LEU121 |
| A | SER160 |
| A | ALA161 |
| A | LYS162 |
| A | MG1002 |
| A | HOH1009 |
| A | HOH1019 |
| A | HOH1035 |
| A | HOH1049 |
| A | HOH1077 |
| A | HOH1080 |
| A | HOH1101 |
| A | HOH1218 |
| A | HOH1219 |
| A | HOH1226 |
| A | HOH1230 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GNP B 1003 |
| Chain | Residue |
| B | GLY14 |
| B | ALA15 |
| B | CYS16 |
| B | GLY17 |
| B | LYS18 |
| B | THR19 |
| B | CYS20 |
| B | PHE30 |
| B | THR37 |
| B | GLY62 |
| B | LYS118 |
| B | ASP120 |
| B | LEU121 |
| B | SER160 |
| B | ALA161 |
| B | LYS162 |
| B | MG1004 |
| B | HOH1010 |
| B | HOH1012 |
| B | HOH1027 |
| B | HOH1053 |
| B | HOH1059 |
| B | HOH1060 |
| B | HOH1065 |
| B | HOH1124 |
| B | HOH1127 |
| B | HOH1132 |
| B | HOH1176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17497936","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GCP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17497936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GCN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17497936","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GCO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GCP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15864301","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17497936","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z2C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GCN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GCO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GCP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17497936","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GCO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLN63 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLN63 |
