2GC7

Substrate reduced, copper free complex of methylamine dehydrogenase, amicyanin and cytochrome c551i from Paracoccus denitrificans.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0030058	molecular_function	aliphatic amine dehydrogenase activity
A	0030416	biological_process	methylamine metabolic process
A	0042597	cellular_component	periplasmic space
A	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
B	0009308	biological_process	amine metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016638	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0042597	cellular_component	periplasmic space
B	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
C	0005507	molecular_function	copper ion binding
C	0009055	molecular_function	electron transfer activity
C	0042597	cellular_component	periplasmic space
C	0046872	molecular_function	metal ion binding
D	0005506	molecular_function	iron ion binding
D	0009055	molecular_function	electron transfer activity
D	0015945	biological_process	methanol metabolic process
D	0020037	molecular_function	heme binding
D	0042597	cellular_component	periplasmic space
D	0046872	molecular_function	metal ion binding
E	0016491	molecular_function	oxidoreductase activity
E	0030058	molecular_function	aliphatic amine dehydrogenase activity
E	0030416	biological_process	methylamine metabolic process
E	0042597	cellular_component	periplasmic space
E	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
F	0009308	biological_process	amine metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016638	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors
F	0030288	cellular_component	outer membrane-bounded periplasmic space
F	0042597	cellular_component	periplasmic space
F	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
G	0005507	molecular_function	copper ion binding
G	0009055	molecular_function	electron transfer activity
G	0042597	cellular_component	periplasmic space
G	0046872	molecular_function	metal ion binding
H	0005506	molecular_function	iron ion binding
H	0009055	molecular_function	electron transfer activity
H	0015945	biological_process	methanol metabolic process
H	0020037	molecular_function	heme binding
H	0042597	cellular_component	periplasmic space
H	0046872	molecular_function	metal ion binding
I	0016491	molecular_function	oxidoreductase activity
I	0030058	molecular_function	aliphatic amine dehydrogenase activity
I	0030416	biological_process	methylamine metabolic process
I	0042597	cellular_component	periplasmic space
I	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
J	0009308	biological_process	amine metabolic process
J	0016491	molecular_function	oxidoreductase activity
J	0016638	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors
J	0030288	cellular_component	outer membrane-bounded periplasmic space
J	0042597	cellular_component	periplasmic space
J	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
K	0005507	molecular_function	copper ion binding
K	0009055	molecular_function	electron transfer activity
K	0042597	cellular_component	periplasmic space
K	0046872	molecular_function	metal ion binding
L	0005506	molecular_function	iron ion binding
L	0009055	molecular_function	electron transfer activity
L	0015945	biological_process	methanol metabolic process
L	0020037	molecular_function	heme binding
L	0042597	cellular_component	periplasmic space
L	0046872	molecular_function	metal ion binding
M	0016491	molecular_function	oxidoreductase activity
M	0030058	molecular_function	aliphatic amine dehydrogenase activity
M	0030416	biological_process	methylamine metabolic process
M	0042597	cellular_component	periplasmic space
M	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
N	0009308	biological_process	amine metabolic process
N	0016491	molecular_function	oxidoreductase activity
N	0016638	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors
N	0030288	cellular_component	outer membrane-bounded periplasmic space
N	0042597	cellular_component	periplasmic space
N	0052876	molecular_function	methylamine dehydrogenase (amicyanin) activity
O	0005507	molecular_function	copper ion binding
O	0009055	molecular_function	electron transfer activity
O	0042597	cellular_component	periplasmic space
O	0046872	molecular_function	metal ion binding
P	0005506	molecular_function	iron ion binding
P	0009055	molecular_function	electron transfer activity
P	0015945	biological_process	methanol metabolic process
P	0020037	molecular_function	heme binding
P	0042597	cellular_component	periplasmic space
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA L 601

Chain	Residue
K	GLU31
L	GLY72
L	ASP75
L	TYR77
L	HOH1051
L	HOH1475

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NA D 602

Chain	Residue
D	ASP75
D	TYR77
D	HOH1003
D	HOH2007
D	HOH2229
C	GLU31
C	HOH2228
D	GLY72

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA P 603

Chain	Residue
O	GLU31
O	HOH1447
P	GLY72
P	ASP75
P	TYR77
P	HOH1330
P	HOH2230

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA H 604

Chain	Residue
G	GLU31
G	HOH1641
H	GLY72
H	ASP75
H	TYR77
H	HOH1084
H	HOH1595

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEC D 200

Chain	Residue
D	MET56
D	CYS57
D	CYS60
D	HIS61
D	PRO71
D	TRP78
D	THR79
D	TYR80
D	ASN83
D	LEU89
D	LEU93
D	ALA97
D	THR98
D	GLN100
D	MET101
D	HOH2007

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEC H 200

Chain	Residue
H	MET56
H	CYS57
H	CYS60
H	HIS61
H	PRO71
H	LEU73
H	TRP78
H	THR79
H	TYR80
H	ASN83
H	LEU89
H	LEU93
H	ALA97
H	THR98
H	GLN100
H	MET101
H	HOH1595

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEC L 200

Chain	Residue
L	MET56
L	CYS57
L	CYS60
L	HIS61
L	PRO71
L	TRP78
L	THR79
L	TYR80
L	ASN83
L	LEU89
L	ALA97
L	THR98
L	GLN100
L	MET101
L	HOH1475
L	HOH2048

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEC P 200

Chain	Residue
P	MET56
P	CYS57
P	CYS60
P	HIS61
P	PRO71
P	LEU73
P	TRP78
P	THR79
P	TYR80
P	ASN83
P	LEU93
P	ALA97
P	THR98
P	GLN100
P	MET101
P	HOH2230

---

Functional Information from PROSITE/UniProt

site_id	PS00196
Number of Residues	14
Details	COPPER_BLUE Type-1 copper (blue) proteins signature. AgtYdYHCt.P.Hpf..M

Chain	Residue	Details
C	ALA85-MET98

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Tryptophylquinone","evidences":[{"source":"PubMed","id":"1409575","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	416
Details	Domain: {"description":"Plastocyanin-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"description":"covalent"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 2bbk

Chain	Residue	Details
B	ASP76
B	THR122
B	ASP32
B	TYR119
B	TRP108

---

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 2bbk

Chain	Residue	Details
F	ASP76
F	THR122
F	ASP32
F	TYR119
F	TRP108

---

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 2bbk

Chain	Residue	Details
J	ASP76
J	THR122
J	ASP32
J	TYR119
J	TRP108

---

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 2bbk

Chain	Residue	Details
N	ASP76
N	THR122
N	ASP32
N	TYR119
N	TRP108

---

site_id	MCSA1
Number of Residues	6
Details	M-CSA 13

Chain	Residue	Details
B	ASP32	electrostatic stabiliser, proton acceptor, proton donor
B	TRQ57	proton acceptor, proton donor, proton relay
B	TYR80	electrostatic stabiliser, proton acceptor, proton donor
B	ALA112	proton acceptor, proton donor, proton relay, single electron donor
B	ILE123	steric role
B	ILE126	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 13

Chain	Residue	Details
F	ASP32	electrostatic stabiliser, proton acceptor, proton donor
F	TRQ57	proton acceptor, proton donor, proton relay
F	TYR80	electrostatic stabiliser, proton acceptor, proton donor
F	ALA112	proton acceptor, proton donor, proton relay, single electron donor
F	ILE123	steric role
F	ILE126	electrostatic stabiliser

---

site_id	MCSA3
Number of Residues	6
Details	M-CSA 13

Chain	Residue	Details
J	ASP32	electrostatic stabiliser, proton acceptor, proton donor
J	TRQ57	proton acceptor, proton donor, proton relay
J	TYR80	electrostatic stabiliser, proton acceptor, proton donor
J	ALA112	proton acceptor, proton donor, proton relay, single electron donor
J	ILE123	steric role
J	ILE126	electrostatic stabiliser

---

site_id	MCSA4
Number of Residues	6
Details	M-CSA 13

Chain	Residue	Details
N	ASP32	electrostatic stabiliser, proton acceptor, proton donor
N	TRQ57	proton acceptor, proton donor, proton relay
N	TYR80	electrostatic stabiliser, proton acceptor, proton donor
N	ALA112	proton acceptor, proton donor, proton relay, single electron donor
N	ILE123	steric role
N	ILE126	electrostatic stabiliser

---