2GC6
S73A mutant of L. casei FPGS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004326 | molecular_function | tetrahydrofolylpolyglutamate synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0006761 | biological_process | dihydrofolate biosynthetic process |
| A | 0008841 | molecular_function | dihydrofolate synthase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016881 | molecular_function | acid-amino acid ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046901 | biological_process | tetrahydrofolylpolyglutamate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 900 |
| Chain | Residue |
| A | GLY49 |
| A | LYS50 |
| A | GLY51 |
| A | SER52 |
| A | TRP297 |
| A | ARG300 |
| A | HOH642 |
Functional Information from PROSITE/UniProt
| site_id | PS01011 |
| Number of Residues | 24 |
| Details | FOLYLPOLYGLU_SYNT_1 Folylpolyglutamate synthase signature 1. IhVTGTNGKgSaanaIaHVLeas.G |
| Chain | Residue | Details |
| A | ILE42-GLY65 |
| site_id | PS01012 |
| Number of Residues | 16 |
| Details | FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. VIEvGIGGdtDsTnVI |
| Chain | Residue | Details |
| A | VAL141-ILE156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11501996","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1JBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JBW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11501996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JBW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11501996","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1JBW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11501996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JBV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11501996","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JBW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| A | LYS50 |
