2GC6

S73A mutant of L. casei FPGS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004326	molecular_function	tetrahydrofolylpolyglutamate synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006730	biological_process	one-carbon metabolic process
A	0006761	biological_process	dihydrofolate biosynthetic process
A	0008841	molecular_function	dihydrofolate synthase activity
A	0009058	biological_process	biosynthetic process
A	0009396	biological_process	folic acid-containing compound biosynthetic process
A	0016874	molecular_function	ligase activity
A	0016881	molecular_function	acid-amino acid ligase activity
A	0046872	molecular_function	metal ion binding
A	0046901	biological_process	tetrahydrofolylpolyglutamate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 900

Chain	Residue
A	GLY49
A	LYS50
A	GLY51
A	SER52
A	TRP297
A	ARG300
A	HOH642

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Functional Information from PROSITE/UniProt

site_id	PS01011
Number of Residues	24
Details	FOLYLPOLYGLU_SYNT_1 Folylpolyglutamate synthase signature 1. IhVTGTNGKgSaanaIaHVLeas.G

Chain	Residue	Details
A	ILE42-GLY65

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site_id	PS01012
Number of Residues	16
Details	FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. VIEvGIGGdtDsTnVI

Chain	Residue	Details
A	VAL141-ILE156

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:11501996, ECO:0007744|PDB:1JBV, ECO:0007744|PDB:1JBW

Chain	Residue	Details
A	ASP313
A	GLY49
A	ARG300

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:11501996, ECO:0007744|PDB:1JBV, ECO:0007744|PDB:1JBW

Chain	Residue	Details
A	ALA73
A	GLU143

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:11501996, ECO:0007744|PDB:1JBW

Chain	Residue	Details
A	ARG82
A	ASN264
A	SER417
A	PHE75

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:11501996, ECO:0007744|PDB:1JBV

Chain	Residue	Details
A	HIS170

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:11501996, ECO:0007744|PDB:1JBV, ECO:0007744|PDB:1JBW

Chain	Residue	Details
A	KCX185

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