2GAM

X-ray crystal structure of murine leukocyte-type Core 2 b1,6-N-acetylglucosaminyltransferase (C2GnT-L) in complex with Galb1,3GalNAc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0003829	molecular_function	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
A	0005615	cellular_component	extracellular space
A	0005802	cellular_component	trans-Golgi network
A	0006486	biological_process	protein glycosylation
A	0009101	biological_process	glycoprotein biosynthetic process
A	0016020	cellular_component	membrane
A	0016266	biological_process	protein O-linked glycosylation via N-acetyl-galactosamine
A	0016268	biological_process	obsolete core 2 O-glycan biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0031985	cellular_component	Golgi cisterna
A	0032868	biological_process	response to insulin
A	0048729	biological_process	tissue morphogenesis
A	0050901	biological_process	leukocyte tethering or rolling
A	0060352	biological_process	cell adhesion molecule production
A	0060993	biological_process	kidney morphogenesis
A	1903238	biological_process	positive regulation of leukocyte tethering or rolling
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0003829	molecular_function	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
B	0005615	cellular_component	extracellular space
B	0005802	cellular_component	trans-Golgi network
B	0006486	biological_process	protein glycosylation
B	0009101	biological_process	glycoprotein biosynthetic process
B	0016020	cellular_component	membrane
B	0016266	biological_process	protein O-linked glycosylation via N-acetyl-galactosamine
B	0016268	biological_process	obsolete core 2 O-glycan biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0031985	cellular_component	Golgi cisterna
B	0032868	biological_process	response to insulin
B	0048729	biological_process	tissue morphogenesis
B	0050901	biological_process	leukocyte tethering or rolling
B	0060352	biological_process	cell adhesion molecule production
B	0060993	biological_process	kidney morphogenesis
B	1903238	biological_process	positive regulation of leukocyte tethering or rolling
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0003829	molecular_function	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
C	0005615	cellular_component	extracellular space
C	0005802	cellular_component	trans-Golgi network
C	0006486	biological_process	protein glycosylation
C	0009101	biological_process	glycoprotein biosynthetic process
C	0016020	cellular_component	membrane
C	0016266	biological_process	protein O-linked glycosylation via N-acetyl-galactosamine
C	0016268	biological_process	obsolete core 2 O-glycan biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0031985	cellular_component	Golgi cisterna
C	0032868	biological_process	response to insulin
C	0048729	biological_process	tissue morphogenesis
C	0050901	biological_process	leukocyte tethering or rolling
C	0060352	biological_process	cell adhesion molecule production
C	0060993	biological_process	kidney morphogenesis
C	1903238	biological_process	positive regulation of leukocyte tethering or rolling
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0003829	molecular_function	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
D	0005615	cellular_component	extracellular space
D	0005802	cellular_component	trans-Golgi network
D	0006486	biological_process	protein glycosylation
D	0009101	biological_process	glycoprotein biosynthetic process
D	0016020	cellular_component	membrane
D	0016266	biological_process	protein O-linked glycosylation via N-acetyl-galactosamine
D	0016268	biological_process	obsolete core 2 O-glycan biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0031985	cellular_component	Golgi cisterna
D	0032868	biological_process	response to insulin
D	0048729	biological_process	tissue morphogenesis
D	0050901	biological_process	leukocyte tethering or rolling
D	0060352	biological_process	cell adhesion molecule production
D	0060993	biological_process	kidney morphogenesis
D	1903238	biological_process	positive regulation of leukocyte tethering or rolling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"16829524","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22056345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16829524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GAM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12954635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16829524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22056345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OTK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---