2GA9
Crystal Structure of the Heterodimeric Vaccinia Virus Polyadenylate Polymerase with Bound ATP-gamma-S
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0031440 | biological_process | regulation of mRNA 3'-end processing |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006397 | biological_process | mRNA processing |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 1990817 | molecular_function | poly(A) RNA polymerase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA D 480 |
| Chain | Residue |
| D | ASP202 |
| D | ASP204 |
| D | AGS482 |
| D | HOH494 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA D 481 |
| Chain | Residue |
| D | ASP202 |
| D | ASP204 |
| D | HOH621 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE AGS D 482 |
| Chain | Residue |
| D | SER188 |
| D | ASP204 |
| D | GLN281 |
| D | ASN284 |
| D | MET285 |
| D | MET288 |
| D | ARG294 |
| D | LYS304 |
| D | ASN402 |
| D | CA480 |
| D | HOH492 |
| D | HOH551 |
| D | HOH575 |
| D | HOH607 |
| D | TYR186 |
| D | GLY187 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE AGS D 483 |
| Chain | Residue |
| D | PHE47 |
| D | ASN48 |
| D | ILE51 |
| D | PHE52 |
| D | LEU55 |
| D | THR109 |
| D | GLY113 |
| D | THR116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Region: {"description":"Binding to NPH-I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For methyltransferase activity","evidences":[{"source":"PubMed","id":"15134442","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00944","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8612277","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PIRSR","id":"PIRSR015693-50","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16678106","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19446524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ERC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
