Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2G97

Crystal Structure of Visfatin/Pre-B Cell Colony Enhancing Factor 1/Nicotinamide Phosphoribosyltransferase In Complex with the Specific Inhibitor FK-866

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001774biological_processmicroglial cell activation
A0005125molecular_functioncytokine activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0007165biological_processsignal transduction
A0007565biological_processfemale pregnancy
A0007623biological_processcircadian rhythm
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD biosynthetic process
A0010507biological_processnegative regulation of autophagy
A0014070biological_processresponse to organic cyclic compound
A0014916biological_processregulation of lung blood pressure
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0032922biological_processcircadian regulation of gene expression
A0042802molecular_functionidentical protein binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
A0060612biological_processadipose tissue development
A0071456biological_processcellular response to hypoxia
A0071479biological_processcellular response to ionizing radiation
A1901363molecular_functionheterocyclic compound binding
A1904646biological_processcellular response to amyloid-beta
A1905377biological_processresponse to D-galactose
A2000773biological_processnegative regulation of cellular senescence
B0000166molecular_functionnucleotide binding
B0001774biological_processmicroglial cell activation
B0005125molecular_functioncytokine activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0007165biological_processsignal transduction
B0007565biological_processfemale pregnancy
B0007623biological_processcircadian rhythm
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD biosynthetic process
B0010507biological_processnegative regulation of autophagy
B0014070biological_processresponse to organic cyclic compound
B0014916biological_processregulation of lung blood pressure
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0032922biological_processcircadian regulation of gene expression
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0051770biological_processpositive regulation of nitric-oxide synthase biosynthetic process
B0060612biological_processadipose tissue development
B0071456biological_processcellular response to hypoxia
B0071479biological_processcellular response to ionizing radiation
B1901363molecular_functionheterocyclic compound binding
B1904646biological_processcellular response to amyloid-beta
B1905377biological_processresponse to D-galactose
B2000773biological_processnegative regulation of cellular senescence
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE DGB A 1001
ChainResidue
AHIS191
AILE351
AGLU376
AASN377
ASER379
AHOH1004
AHOH1016
BTYR18
APHE193
AASP219
AVAL242
AALA244
APRO307
AILE309
AARG311
AARG349

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE DGB B 1002
ChainResidue
ATYR18
BHIS191
BPHE193
BARG196
BASP219
BVAL242
BALA244
BSER275
BARG311
BARG349
BGLU376
BASN377
BSER379
BHOH1042

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG196
BHIS247
BARG311
AASP219
AHIS247
AARG311
BARG196
BASP219

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING:
ChainResidueDetails
AGLY384
AARG392
BGLY353
BGLY384
BARG392
AGLY353

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P43490
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P43490
ChainResidueDetails
ATYR188
BTYR188

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P43490
ChainResidueDetails
ASER472
BSER472

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon