2G73
Y104F mutant type 1 IPP isomerase complex with EIPP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004452 | molecular_function | isopentenyl-diphosphate delta-isomerase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006974 | biological_process | DNA damage response |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0016853 | molecular_function | isomerase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004452 | molecular_function | isopentenyl-diphosphate delta-isomerase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006974 | biological_process | DNA damage response |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0016853 | molecular_function | isomerase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 184 |
Chain | Residue |
A | HIS25 |
A | HIS32 |
A | HIS69 |
A | GLU114 |
A | GLU116 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B 184 |
Chain | Residue |
B | GLU116 |
B | HIS25 |
B | HIS32 |
B | HIS69 |
B | GLU114 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 185 |
Chain | Residue |
A | CYS67 |
A | GLU87 |
A | EIP186 |
A | HOH201 |
A | HOH202 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 185 |
Chain | Residue |
B | CYS67 |
B | GLU87 |
B | EIP186 |
B | HOH203 |
B | HOH204 |
site_id | AC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE EIP A 186 |
Chain | Residue |
A | LYS21 |
A | ALA34 |
A | PHE35 |
A | ARG51 |
A | LYS55 |
A | CYS67 |
A | GLY68 |
A | HIS69 |
A | ARG83 |
A | GLU87 |
A | PHE104 |
A | GLU114 |
A | GLU116 |
A | CYS118 |
A | TRP161 |
A | MG185 |
A | HOH201 |
A | HOH202 |
A | HOH205 |
A | HOH210 |
A | HOH218 |
site_id | AC6 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE EIP B 186 |
Chain | Residue |
B | LYS21 |
B | ARG51 |
B | LYS55 |
B | CYS67 |
B | GLY68 |
B | HIS69 |
B | ARG83 |
B | GLU87 |
B | PHE104 |
B | GLU114 |
B | GLU116 |
B | CYS118 |
B | TRP161 |
B | MG185 |
B | HOH203 |
B | HOH204 |
B | HOH211 |
B | HOH1292 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | CYS67 | |
A | GLU116 | |
B | CYS67 | |
B | GLU116 |
site_id | SWS_FT_FI2 |
Number of Residues | 14 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS21 | |
B | LYS55 | |
B | CYS67 | |
B | HIS69 | |
B | ARG83 | |
B | GLU87 | |
A | ARG51 | |
A | LYS55 | |
A | CYS67 | |
A | HIS69 | |
A | ARG83 | |
A | GLU87 | |
B | LYS21 | |
B | ARG51 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12630859, ECO:0000269|PubMed:15643873 |
Chain | Residue | Details |
A | HIS25 | |
A | HIS32 | |
A | GLU114 | |
A | GLU116 | |
B | HIS25 | |
B | HIS32 | |
B | GLU114 | |
B | GLU116 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Essential for catalytic activity |
Chain | Residue | Details |
A | PHE104 | |
B | PHE104 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1i9a |
Chain | Residue | Details |
A | TRP161 | |
A | GLU87 | |
A | GLU116 | |
A | CYS67 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1i9a |
Chain | Residue | Details |
B | TRP161 | |
B | GLU87 | |
B | GLU116 | |
B | CYS67 |
site_id | MCSA1 |
Number of Residues | 9 |
Details | M-CSA 190 |
Chain | Residue | Details |
A | HIS25 | metal ligand |
A | HIS32 | metal ligand |
A | CYS67 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | HIS69 | metal ligand |
A | GLU87 | metal ligand |
A | PHE104 | hydrogen bond acceptor, hydrogen bond donor, proton donor |
A | GLU114 | metal ligand |
A | GLU116 | electrostatic stabiliser, hydrogen bond acceptor, metal ligand, proton acceptor, proton donor |
A | TRP161 | electrostatic stabiliser, polar/non-polar interaction |
site_id | MCSA2 |
Number of Residues | 9 |
Details | M-CSA 190 |
Chain | Residue | Details |
B | HIS25 | metal ligand |
B | HIS32 | metal ligand |
B | CYS67 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | HIS69 | metal ligand |
B | GLU87 | metal ligand |
B | PHE104 | hydrogen bond acceptor, hydrogen bond donor, proton donor |
B | GLU114 | metal ligand |
B | GLU116 | electrostatic stabiliser, hydrogen bond acceptor, metal ligand, proton acceptor, proton donor |
B | TRP161 | electrostatic stabiliser, polar/non-polar interaction |