2G1P

Structure of E. coli DNA adenine methyltransferase (DAM)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006298	biological_process	mismatch repair
A	0008168	molecular_function	methyltransferase activity
A	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
A	0009307	biological_process	DNA restriction-modification system
A	0009411	biological_process	response to UV
A	0032259	biological_process	methylation
A	0043565	molecular_function	sequence-specific DNA binding
A	1902328	biological_process	bacterial-type DNA replication initiation
A	1904047	molecular_function	S-adenosyl-L-methionine binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006298	biological_process	mismatch repair
B	0008168	molecular_function	methyltransferase activity
B	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
B	0009307	biological_process	DNA restriction-modification system
B	0009411	biological_process	response to UV
B	0032259	biological_process	methylation
B	0043565	molecular_function	sequence-specific DNA binding
B	1902328	biological_process	bacterial-type DNA replication initiation
B	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH A 401

Chain	Residue
A	TRP10
A	ASP54
A	ILE55
A	SER164
A	TYR165
A	ASP181
A	PRO183
A	HOH403
A	HOH409
A	HOH448
A	LYS14
A	PRO34
A	PHE35
A	VAL36
A	GLY37
A	ALA38
A	GLY39
A	SER40

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SAH B 402

Chain	Residue
B	TRP10
B	LYS14
B	PRO34
B	PHE35
B	VAL36
B	GLY37
B	ALA38
B	GLY39
B	SER40
B	ASP54
B	ILE55
B	SER164
B	TYR165
B	ASP181
B	HOH404
B	HOH410
B	HOH429
B	HOH457
B	HOH518

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 397

Chain	Residue
B	TRP10
B	ALA11
B	GLY121
B	LEU122
B	CYS123
B	HOH429
B	HOH479

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Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VYCDPPY

Chain	Residue	Details
A	VAL178-TYR184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	TRP10
A	LYS14
A	ASP54
A	ASP181
B	TRP10
B	LYS14
B	ASP54
B	ASP181

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