2FYF
Structure of a putative phosphoserine aminotransferase from Mycobacterium Tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004648 | molecular_function | O-phospho-L-serine:2-oxoglutarate aminotransferase activity |
| A | 0004760 | molecular_function | L-serine-pyruvate transaminase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006563 | biological_process | L-serine metabolic process |
| A | 0006564 | biological_process | L-serine biosynthetic process |
| A | 0008453 | molecular_function | alanine-glyoxylate transaminase activity |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0008615 | biological_process | pyridoxine biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019265 | biological_process | glycine biosynthetic process, by transamination of glyoxylate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0004648 | molecular_function | O-phospho-L-serine:2-oxoglutarate aminotransferase activity |
| B | 0004760 | molecular_function | L-serine-pyruvate transaminase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006563 | biological_process | L-serine metabolic process |
| B | 0006564 | biological_process | L-serine biosynthetic process |
| B | 0008453 | molecular_function | alanine-glyoxylate transaminase activity |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0008615 | biological_process | pyridoxine biosynthetic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019265 | biological_process | glycine biosynthetic process, by transamination of glyoxylate |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1387 |
| Chain | Residue |
| A | TYR341 |
| A | ARG342 |
| B | HIS49 |
| B | ARG50 |
| B | HOH2548 |
| B | HOH2597 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2392 |
| Chain | Residue |
| A | HOH2784 |
| B | TYR341 |
| B | ARG342 |
| A | HIS49 |
| A | ARG50 |
| A | HOH2540 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PC4 A 1382 |
| Chain | Residue |
| A | GLU263 |
| A | TRP267 |
| A | HOH2827 |
| A | HOH2828 |
| A | HOH2829 |
| A | HOH2830 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PC4 B 2386 |
| Chain | Residue |
| B | GLU32 |
| B | HOH2801 |
| B | HOH2802 |
| B | HOH2803 |
| B | HOH2804 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PC4 B 2391 |
| Chain | Residue |
| B | GLU107 |
| B | HOH2659 |
| B | HOH2680 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP A 1377 |
| Chain | Residue |
| A | ALA84 |
| A | THR85 |
| A | TRP88 |
| A | PHE108 |
| A | ASN152 |
| A | THR154 |
| A | ASP176 |
| A | THR178 |
| A | ALA197 |
| A | GLN199 |
| A | LYS200 |
| A | HOH2406 |
| A | HOH2662 |
| B | ASN251 |
| B | THR252 |
| B | HOH2452 |
| B | HOH2548 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PC4 A 1378 |
| Chain | Residue |
| A | HIS8 |
| A | LEU9 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP B 2377 |
| Chain | Residue |
| A | ASN251 |
| A | THR252 |
| A | HOH2540 |
| B | ALA84 |
| B | THR85 |
| B | TRP88 |
| B | PHE108 |
| B | ASN152 |
| B | THR154 |
| B | ASP176 |
| B | THR178 |
| B | ALA197 |
| B | GLN199 |
| B | LYS200 |
| B | HOH2397 |
| B | HOH2448 |
| B | HOH2749 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PC4 B 2378 |
| Chain | Residue |
| B | ARG30 |
| B | GLN33 |
| B | GLU263 |
| B | ASP266 |
| B | TRP267 |
| B | HOH2775 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PC4 B 2383 |
| Chain | Residue |
| B | HIS8 |
| B | LEU9 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1388 |
| Chain | Residue |
| A | ARG62 |
| A | SER63 |
| A | ALA66 |
| A | GLU76 |
| A | VAL77 |
| A | HOH2641 |
| A | HOH2659 |
| A | HOH2748 |
| A | HOH2806 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 1389 |
| Chain | Residue |
| A | ARG375 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1390 |
| Chain | Residue |
| A | ARG331 |
| A | HOH2684 |
| A | HOH2824 |
| B | ALA52 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 2393 |
| Chain | Residue |
| B | ARG62 |
| B | SER63 |
| B | GLU76 |
| B | VAL77 |
| B | HOH2603 |
| B | HOH2768 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 2394 |
| Chain | Residue |
| A | ALA52 |
| A | PRO53 |
| A | HOH2477 |
| B | ARG331 |
| B | HOH2552 |
| B | HOH2780 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL B 2395 |
| Chain | Residue |
| B | ARG375 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 2396 |
| Chain | Residue |
| B | GLY20 |
| B | ASN333 |
| B | GLY334 |
| B | LYS16 |
| B | PRO17 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22525753","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| A | TYR105 | |
| A | ASP176 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| B | TYR105 | |
| B | ASP176 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| A | LYS200 | |
| A | PHE108 | |
| A | ASP176 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bjo |
| Chain | Residue | Details |
| B | LYS200 | |
| B | PHE108 | |
| B | ASP176 |
