Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2FVZ

Human Inositol Monophosphosphatase 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006020	biological_process	inositol metabolic process
A	0006021	biological_process	inositol biosynthetic process
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0007165	biological_process	signal transduction
A	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
A	0010226	biological_process	response to lithium ion
A	0016787	molecular_function	hydrolase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
A	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
A	0052834	molecular_function	inositol monophosphate phosphatase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006020	biological_process	inositol metabolic process
B	0006021	biological_process	inositol biosynthetic process
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0007165	biological_process	signal transduction
B	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
B	0010226	biological_process	response to lithium ion
B	0016787	molecular_function	hydrolase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
B	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
B	0052834	molecular_function	inositol monophosphate phosphatase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006020	biological_process	inositol metabolic process
C	0006021	biological_process	inositol biosynthetic process
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0007165	biological_process	signal transduction
C	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
C	0010226	biological_process	response to lithium ion
C	0016787	molecular_function	hydrolase activity
C	0042803	molecular_function	protein homodimerization activity
C	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
C	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
C	0052834	molecular_function	inositol monophosphate phosphatase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006020	biological_process	inositol metabolic process
D	0006021	biological_process	inositol biosynthetic process
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0007165	biological_process	signal transduction
D	0008934	molecular_function	inositol monophosphate 1-phosphatase activity
D	0010226	biological_process	response to lithium ion
D	0016787	molecular_function	hydrolase activity
D	0042803	molecular_function	protein homodimerization activity
D	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0052832	molecular_function	inositol monophosphate 3-phosphatase activity
D	0052833	molecular_function	inositol monophosphate 4-phosphatase activity
D	0052834	molecular_function	inositol monophosphate phosphatase activity

Functional Information from PROSITE/UniProt

site_id	PS00629
Number of Residues	14
Details	IMP_1 Inositol monophosphatase family signature 1. WiIDPIDGTcnFvH

Chain	Residue	Details
A	TRP98-HIS111

site_id	PS00630
Number of Residues	15
Details	IMP_2 Inositol monophosphatase family signature 2. WDlAAAtVIIreaGG

Chain	Residue	Details
A	TRP230-GLY244

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:17340635

Chain	Residue	Details
A	GLU81
A	GLN224
B	GLU81
B	GLN224
C	GLU81
C	GLN224
D	GLU81
D	GLN224

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P29218

Chain	Residue	Details
A	ASP101
D	ASP101
D	ILE103
D	ASP104
A	ILE103
A	ASP104
B	ASP101
B	ILE103
B	ASP104
C	ASP101
C	ILE103
C	ASP104

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	GLY205
B	GLY205
C	GLY205
D	GLY205

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP231
B	ASP231
C	ASP231
D	ASP231

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
A	GLU81
A	THR106

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
B	ASP58
B	ASP231
B	THR106

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
C	ASP58
C	ASP231
C	THR106

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
D	ASP58
D	ASP231
D	THR106

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
B	GLU81
B	THR106

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
C	GLU81
C	THR106

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
D	GLU81
D	THR106

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
A	THR106

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
B	THR106

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
C	THR106

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
D	THR106

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
A	ASP58
A	ASP231
A	THR106

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)