2FVV
Human Diphosphoinositol polyphosphate phosphohydrolase 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000298 | molecular_function | endopolyphosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008486 | molecular_function | diphosphoinositol-polyphosphate diphosphatase activity |
| A | 0015961 | biological_process | diadenosine polyphosphate catabolic process |
| A | 0016462 | molecular_function | pyrophosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0034431 | molecular_function | bis(5'-adenosyl)-hexaphosphatase activity |
| A | 0034432 | molecular_function | bis(5'-adenosyl)-pentaphosphatase activity |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052840 | molecular_function | inositol diphosphate tetrakisphosphate diphosphatase activity |
| A | 0052842 | molecular_function | inositol diphosphate pentakisphosphate diphosphatase activity |
| A | 0052845 | molecular_function | inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
| A | 0052848 | molecular_function | inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
| A | 0071543 | biological_process | diphosphoinositol polyphosphate metabolic process |
| A | 0071544 | biological_process | diphosphoinositol polyphosphate catabolic process |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0110154 | biological_process | RNA decapping |
| A | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| A | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| A | 1901907 | biological_process | diadenosine pentaphosphate catabolic process |
| A | 1901909 | biological_process | diadenosine hexaphosphate catabolic process |
| A | 1901911 | biological_process | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 2361 |
| Chain | Residue |
| A | SER28 |
| A | SER30 |
| A | GLU31 |
| A | GLU32 |
| A | GLU33 |
| A | HOH4004 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3001 |
| Chain | Residue |
| A | LYS133 |
| A | VAL135 |
| A | GLN136 |
| A | TYR139 |
| A | HOH4005 |
| A | HOH4010 |
| A | HOH4075 |
| A | HOH4237 |
| A | ARG20 |
| A | ASN86 |
| A | HIS91 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE IHP A 2360 |
| Chain | Residue |
| A | ARG10 |
| A | LYS18 |
| A | ARG20 |
| A | SER39 |
| A | ARG41 |
| A | ARG89 |
| A | HIS91 |
| A | LYS133 |
| A | HOH4027 |
| A | HOH4031 |
| A | HOH4037 |
| A | HOH4049 |
| A | HOH4051 |
| A | HOH4053 |
| A | HOH4054 |
| A | HOH4060 |
| A | HOH4083 |
| A | HOH4089 |
| A | HOH4224 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG |
| Chain | Residue | Details |
| A | GLY51-GLY72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 125 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
