2FVV

Human Diphosphoinositol polyphosphate phosphohydrolase 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000298	molecular_function	endopolyphosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007267	biological_process	cell-cell signaling
A	0008270	molecular_function	zinc ion binding
A	0008486	molecular_function	diphosphoinositol-polyphosphate diphosphatase activity
A	0015961	biological_process	diadenosine polyphosphate catabolic process
A	0016462	molecular_function	pyrophosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0034431	molecular_function	bis(5'-adenosyl)-hexaphosphatase activity
A	0034432	molecular_function	bis(5'-adenosyl)-pentaphosphatase activity
A	0046872	molecular_function	metal ion binding
A	0052840	molecular_function	inositol diphosphate tetrakisphosphate diphosphatase activity
A	0052842	molecular_function	inositol diphosphate pentakisphosphate diphosphatase activity
A	0052845	molecular_function	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
A	0052848	molecular_function	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
A	0071543	biological_process	diphosphoinositol polyphosphate metabolic process
A	0071544	biological_process	diphosphoinositol polyphosphate catabolic process
A	0110154	biological_process	RNA decapping
A	0140932	molecular_function	5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
A	1901907	biological_process	diadenosine pentaphosphate catabolic process
A	1901909	biological_process	diadenosine hexaphosphate catabolic process
A	1901911	biological_process	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 2361

Chain	Residue
A	SER28
A	SER30
A	GLU31
A	GLU32
A	GLU33
A	HOH4004

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A 3001

Chain	Residue
A	LYS133
A	VAL135
A	GLN136
A	TYR139
A	HOH4005
A	HOH4010
A	HOH4075
A	HOH4237
A	ARG20
A	ASN86
A	HIS91

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE IHP A 2360

Chain	Residue
A	ARG10
A	LYS18
A	ARG20
A	SER39
A	ARG41
A	ARG89
A	HIS91
A	LYS133
A	HOH4027
A	HOH4031
A	HOH4037
A	HOH4049
A	HOH4051
A	HOH4053
A	HOH4054
A	HOH4060
A	HOH4083
A	HOH4089
A	HOH4224

---

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG

Chain	Residue	Details
A	GLY51-GLY72

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305

Chain	Residue	Details
A	GLU69

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2FVV, ECO:0007744|PDB:2Q9P

Chain	Residue	Details
A	ARG10
A	LYS18
A	SER39
A	ARG89
A	LYS133

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2Q9P

Chain	Residue	Details
A	GLY50
A	GLU66
A	GLU70
A	ARG115

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1

---