Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2FUG

Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005886	cellular_component	plasma membrane
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0010181	molecular_function	FMN binding
1	0045271	cellular_component	respiratory chain complex I
1	0051287	molecular_function	NAD binding
1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
1	1902600	biological_process	proton transmembrane transport
2	0003954	molecular_function	NADH dehydrogenase activity
2	0005886	cellular_component	plasma membrane
2	0016491	molecular_function	oxidoreductase activity
2	0030964	cellular_component	NADH dehydrogenase complex
3	0005886	cellular_component	plasma membrane
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0016491	molecular_function	oxidoreductase activity
3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
3	0042773	biological_process	ATP synthesis coupled electron transport
3	0043546	molecular_function	molybdopterin cofactor binding
3	0051536	molecular_function	iron-sulfur cluster binding
3	1902600	biological_process	proton transmembrane transport
4	0005886	cellular_component	plasma membrane
4	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4	0048038	molecular_function	quinone binding
4	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
4	0051287	molecular_function	NAD binding
5	0005886	cellular_component	plasma membrane
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
5	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
5	1902600	biological_process	proton transmembrane transport
6	0005506	molecular_function	iron ion binding
6	0005886	cellular_component	plasma membrane
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0009060	biological_process	aerobic respiration
6	0015990	biological_process	electron transport coupled proton transport
6	0045271	cellular_component	respiratory chain complex I
6	0048038	molecular_function	quinone binding
6	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
6	0051536	molecular_function	iron-sulfur cluster binding
6	0051539	molecular_function	4 iron, 4 sulfur cluster binding
7	0005886	cellular_component	plasma membrane
7	0008199	molecular_function	ferric iron binding
7	0016226	biological_process	iron-sulfur cluster assembly
9	0003954	molecular_function	NADH dehydrogenase activity
9	0005506	molecular_function	iron ion binding
9	0005886	cellular_component	plasma membrane
9	0009060	biological_process	aerobic respiration
9	0016020	cellular_component	membrane
9	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
9	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
9	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0005886	cellular_component	plasma membrane
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0010181	molecular_function	FMN binding
A	0045271	cellular_component	respiratory chain complex I
A	0051287	molecular_function	NAD binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	1902600	biological_process	proton transmembrane transport
B	0003954	molecular_function	NADH dehydrogenase activity
B	0005886	cellular_component	plasma membrane
B	0016491	molecular_function	oxidoreductase activity
B	0030964	cellular_component	NADH dehydrogenase complex
C	0005886	cellular_component	plasma membrane
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0042773	biological_process	ATP synthesis coupled electron transport
C	0043546	molecular_function	molybdopterin cofactor binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	1902600	biological_process	proton transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0048038	molecular_function	quinone binding
D	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
D	0051287	molecular_function	NAD binding
E	0005886	cellular_component	plasma membrane
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
E	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
E	1902600	biological_process	proton transmembrane transport
F	0005506	molecular_function	iron ion binding
F	0005886	cellular_component	plasma membrane
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0009060	biological_process	aerobic respiration
F	0015990	biological_process	electron transport coupled proton transport
F	0045271	cellular_component	respiratory chain complex I
F	0048038	molecular_function	quinone binding
F	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0003954	molecular_function	NADH dehydrogenase activity
G	0005506	molecular_function	iron ion binding
G	0005886	cellular_component	plasma membrane
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
H	0005886	cellular_component	plasma membrane
H	0008199	molecular_function	ferric iron binding
H	0016226	biological_process	iron-sulfur cluster assembly
J	0005886	cellular_component	plasma membrane
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0010181	molecular_function	FMN binding
J	0045271	cellular_component	respiratory chain complex I
J	0051287	molecular_function	NAD binding
J	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	1902600	biological_process	proton transmembrane transport
K	0003954	molecular_function	NADH dehydrogenase activity
K	0005886	cellular_component	plasma membrane
K	0016491	molecular_function	oxidoreductase activity
K	0030964	cellular_component	NADH dehydrogenase complex
L	0005886	cellular_component	plasma membrane
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0043546	molecular_function	molybdopterin cofactor binding
L	0051536	molecular_function	iron-sulfur cluster binding
L	1902600	biological_process	proton transmembrane transport
M	0005886	cellular_component	plasma membrane
M	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
M	0048038	molecular_function	quinone binding
M	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
M	0051287	molecular_function	NAD binding
N	0005886	cellular_component	plasma membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
N	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
N	1902600	biological_process	proton transmembrane transport
O	0005506	molecular_function	iron ion binding
O	0005886	cellular_component	plasma membrane
O	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
O	0009060	biological_process	aerobic respiration
O	0015990	biological_process	electron transport coupled proton transport
O	0045271	cellular_component	respiratory chain complex I
O	0048038	molecular_function	quinone binding
O	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
O	0051536	molecular_function	iron-sulfur cluster binding
O	0051539	molecular_function	4 iron, 4 sulfur cluster binding
P	0003954	molecular_function	NADH dehydrogenase activity
P	0005506	molecular_function	iron ion binding
P	0005886	cellular_component	plasma membrane
P	0009060	biological_process	aerobic respiration
P	0016020	cellular_component	membrane
P	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
P	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
P	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Q	0005886	cellular_component	plasma membrane
Q	0008199	molecular_function	ferric iron binding
Q	0016226	biological_process	iron-sulfur cluster assembly
S	0005886	cellular_component	plasma membrane
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0010181	molecular_function	FMN binding
S	0045271	cellular_component	respiratory chain complex I
S	0051287	molecular_function	NAD binding
S	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S	1902600	biological_process	proton transmembrane transport
T	0003954	molecular_function	NADH dehydrogenase activity
T	0005886	cellular_component	plasma membrane
T	0016491	molecular_function	oxidoreductase activity
T	0030964	cellular_component	NADH dehydrogenase complex
U	0005886	cellular_component	plasma membrane
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0016020	cellular_component	membrane
U	0016491	molecular_function	oxidoreductase activity
U	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
U	0042773	biological_process	ATP synthesis coupled electron transport
U	0043546	molecular_function	molybdopterin cofactor binding
U	0051536	molecular_function	iron-sulfur cluster binding
U	1902600	biological_process	proton transmembrane transport
V	0005886	cellular_component	plasma membrane
V	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
V	0048038	molecular_function	quinone binding
V	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
V	0051287	molecular_function	NAD binding
W	0005886	cellular_component	plasma membrane
W	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
W	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
W	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
W	1902600	biological_process	proton transmembrane transport
X	0005506	molecular_function	iron ion binding
X	0005886	cellular_component	plasma membrane
X	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
X	0009060	biological_process	aerobic respiration
X	0015990	biological_process	electron transport coupled proton transport
X	0045271	cellular_component	respiratory chain complex I
X	0048038	molecular_function	quinone binding
X	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
X	0051536	molecular_function	iron-sulfur cluster binding
X	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Y	0003954	molecular_function	NADH dehydrogenase activity
Y	0005506	molecular_function	iron ion binding
Y	0005886	cellular_component	plasma membrane
Y	0009060	biological_process	aerobic respiration
Y	0016020	cellular_component	membrane
Y	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Y	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
Y	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Z	0005886	cellular_component	plasma membrane
Z	0008199	molecular_function	ferric iron binding
Z	0016226	biological_process	iron-sulfur cluster assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 6 182

Chain	Residue
4	ARG84
4	HIS169
6	CYS45
6	CYS46
6	GLY82
6	ALA110
6	CYS111
6	CYS140
6	PRO141

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 9 183

Chain	Residue
9	HIS41
9	CYS63
9	PRO64
9	CYS98
9	ILE99
9	PHE100
9	CYS101
9	CYS104

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SF4 9 184

Chain	Residue
9	CYS53
9	ILE54
9	CYS56
9	CYS59
9	CYS108
9	THR110

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 3 784

Chain	Residue
3	HIS115
3	ASP118
3	CYS119
3	CYS122
3	CYS128
3	GLN131
3	VAL232
3	GLY233

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SF4 3 785

Chain	Residue
3	CYS181
3	ILE182
3	CYS184
3	CYS187
3	CYS230
3	VAL232
3	LEU235

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 3 786

Chain	Residue
3	CYS256
3	LEU258
3	CYS259
3	VAL261
3	CYS263
3	ILE290
3	CYS291
3	PRO407

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES 3 787

Chain	Residue
3	CYS34
3	SER35
3	GLY43
3	ALA44
3	CYS45
3	CYS48
3	CYS83

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 1 439

Chain	Residue
1	PRO199
1	SER352
1	CYS353
1	GLY354
1	LYS355
1	CYS356
1	CYS359
1	PHE399
1	CYS400

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES 2 182

Chain	Residue
2	CYS83
2	SER87
2	CYS88
2	CYS124
2	LEU125
2	GLY126
2	SER127
2	CYS128

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE FMN 7 500

Chain	Residue
1	GLY64
1	GLY66
1	THR72
1	LYS75
1	ASN92
1	ASP94
1	GLU95
1	SER96
1	GLU97
1	TYR180
1	GLY183
1	ILE218
1	ASN219
1	ASN220
1	THR223

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 F 182

Chain	Residue
D	ARG84
F	CYS45
F	CYS46
F	GLY82
F	ALA110
F	CYS111
F	CYS140
F	PRO141

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 G 183

Chain	Residue
G	CYS101
G	CYS104
G	HIS41
G	CYS63
G	PRO64
G	CYS98
G	ILE99
G	PHE100

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 G 184

Chain	Residue
G	CYS53
G	ILE54
G	CYS56
G	CYS59
G	CYS108
G	PRO109
G	THR110
G	ILE113

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 C 784

Chain	Residue
C	HIS115
C	ASP118
C	CYS119
C	CYS122
C	CYS128
C	GLN131
C	VAL232
C	GLY233

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SF4 C 785

Chain	Residue
C	CYS181
C	ILE182
C	CYS184
C	CYS187
C	CYS230
C	VAL232
C	LEU235

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 C 786

Chain	Residue
C	CYS256
C	LEU258
C	CYS259
C	VAL261
C	GLY262
C	CYS263
C	ILE290
C	CYS291
C	PRO407

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES C 787

Chain	Residue
C	CYS34
C	SER35
C	GLY43
C	ALA44
C	CYS45
C	CYS48
C	CYS83

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 A 439

Chain	Residue
A	PRO199
A	SER352
A	CYS353
A	GLY354
A	LYS355
A	CYS356
A	CYS359
A	CYS400
A	ALA403

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES B 182

Chain	Residue
B	CYS83
B	SER87
B	CYS88
B	CYS124
B	LEU125
B	GLY126
B	SER127
B	CYS128

site_id	CC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE FMN H 500

Chain	Residue
A	GLY64
A	THR72
A	LYS75
A	ASN92
A	ASP94
A	GLU95
A	SER96
A	GLU97
A	TYR180
A	GLY183
A	ILE218
A	ASN219
A	ASN220
A	THR223

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 O 182

Chain	Residue
M	ARG84
M	HIS169
O	CYS45
O	CYS46
O	GLY82
O	ALA110
O	CYS111
O	CYS140
O	PRO141

site_id	CC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 P 183

Chain	Residue
P	HIS41
P	CYS63
P	PRO64
P	CYS98
P	ILE99
P	PHE100
P	CYS101
P	CYS104

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 P 184

Chain	Residue
P	CYS53
P	ILE54
P	CYS56
P	CYS59
P	CYS108
P	PRO109
P	THR110
P	ILE113

site_id	CC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 L 784

Chain	Residue
L	HIS115
L	ASP118
L	CYS119
L	CYS122
L	CYS128
L	GLN131
L	VAL232
L	GLY233

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SF4 L 785

Chain	Residue
L	CYS181
L	ILE182
L	CYS184
L	CYS187
L	CYS230
L	VAL232
L	LEU235

site_id	CC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 L 786

Chain	Residue
L	CYS256
L	LEU258
L	CYS259
L	VAL261
L	GLY262
L	CYS263
L	ILE290
L	CYS291
L	PRO407

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES L 787

Chain	Residue
L	CYS34
L	SER35
L	GLY43
L	ALA44
L	CYS45
L	MET47
L	CYS48
L	CYS83

site_id	DC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 J 439

Chain	Residue
J	PRO199
J	SER352
J	CYS353
J	GLY354
J	LYS355
J	CYS356
J	CYS359
J	CYS400
J	ALA403

site_id	DC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES K 182

Chain	Residue
K	CYS83
K	SER87
K	CYS88
K	CYS124
K	LEU125
K	GLY126
K	SER127
K	CYS128

site_id	DC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE FMN Q 500

Chain	Residue
J	GLY64
J	THR72
J	LYS75
J	ASN92
J	ASP94
J	GLU95
J	SER96
J	GLU97
J	TYR180
J	GLY183
J	ILE218
J	ASN219
J	ASN220
J	THR223

site_id	DC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 X 182

Chain	Residue
V	ARG84
X	CYS45
X	CYS46
X	GLY82
X	ALA110
X	CYS111
X	CYS140
X	PRO141

site_id	DC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 Y 183

Chain	Residue
Y	HIS41
Y	CYS63
Y	PRO64
Y	CYS98
Y	ILE99
Y	PHE100
Y	CYS101
Y	CYS104

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SF4 Y 184

Chain	Residue
Y	CYS53
Y	ILE54
Y	CYS56
Y	CYS59
Y	CYS108
Y	THR110

site_id	DC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 U 784

Chain	Residue
U	HIS115
U	ASP118
U	CYS119
U	CYS122
U	CYS128
U	LEU130
U	GLN131
U	VAL232
U	GLY233

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SF4 U 785

Chain	Residue
U	CYS181
U	ILE182
U	CYS184
U	CYS187
U	CYS230
U	LEU235

site_id	DC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 U 786

Chain	Residue
U	CYS256
U	LEU258
U	CYS259
U	VAL261
U	GLY262
U	CYS263
U	ILE290
U	CYS291
U	PRO407

site_id	EC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES U 787

Chain	Residue
U	CYS34
U	SER35
U	GLY43
U	ALA44
U	CYS45
U	CYS48
U	CYS83

site_id	EC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SF4 S 439

Chain	Residue
S	PRO199
S	SER352
S	CYS353
S	GLY354
S	LYS355
S	CYS356
S	CYS359
S	PHE399
S	CYS400
S	ALA403

site_id	EC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES T 182

Chain	Residue
T	CYS83
T	SER87
T	CYS88
T	CYS124
T	LEU125
T	GLY126
T	SER127
T	CYS128

site_id	EC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE FMN Z 500

Chain	Residue
S	GLY64
S	GLY66
S	THR72
S	LYS75
S	ASN92
S	ASP94
S	GLU95
S	SER96
S	GLU97
S	GLY183
S	ILE218
S	ASN219
S	ASN220
S	THR223

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCSlCAaACP

Chain	Residue	Details
Y	CYS53-PRO64
Y	CYS98-PRO109

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHTGfEKTmEhR

Chain	Residue	Details
V	LEU62-ARG73

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvyDLFgivfegHpdlRkIL

Chain	Residue	Details
W	GLU115-LEU136

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PlfCSekhlspiGaCRmC

Chain	Residue	Details
U	PRO31-CYS48

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPtCDkGGaCeLQ

Chain	Residue	Details
U	CYS119-GLN131

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCkRCVrY

Chain	Residue	Details
U	ARG180-TYR190

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALMNS

Chain	Residue	Details
1	GLY176-SER191

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGkCtPCReG

Chain	Residue	Details
1	GLU351-GLY362

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvqkveCLGsChtAP

Chain	Residue	Details
2	ASP114-PRO132

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. NvDSVVPVDVYvPgCPP

Chain	Residue	Details
X	ASN126-PRO142

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	188
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16469879","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	156
Details	Domain: {"description":"4Fe-4S His(Cys)3-ligated-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	224
Details	Domain: {"description":"4Fe-4S Mo/W bis-MGD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01004","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16469879","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	120
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	116
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
V	HIS38

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
4	HIS38

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
D	HIS38

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
M	HIS38

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
4	VAL403

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
D	VAL403

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
M	VAL403

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1cc1

Chain	Residue	Details
V	VAL403

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)