2FTP

Crystal Structure of hydroxymethylglutaryl-CoA lyase from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004419	molecular_function	hydroxymethylglutaryl-CoA lyase activity
A	0006552	biological_process	L-leucine catabolic process
A	0008300	biological_process	isoprenoid catabolic process
A	0016829	molecular_function	lyase activity
A	0016833	molecular_function	oxo-acid-lyase activity
A	0046247	biological_process	terpene catabolic process
A	0046872	molecular_function	metal ion binding
A	0046951	biological_process	ketone body biosynthetic process
A	0047445	molecular_function	3-hydroxy-3-isohexenylglutaryl-CoA lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 3000

Chain	Residue
A	ASP16
A	HIS207
A	HIS209
A	ASN249
A	HOH3187

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 2000

Chain	Residue
A	MET59
A	ALA60
A	GLY61
A	SER62
A	ALA63
A	ASN114
A	HOH3167
A	SER49
A	PHE50
A	VAL51
A	PRO53

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 2001

Chain	Residue
A	LYS54
A	PHE101
A	ALA102
A	ALA103
A	ASN112
A	ILE113
A	SER143
A	HOH3037

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Functional Information from PROSITE/UniProt

site_id	PS01062
Number of Residues	10
Details	HMG_COA_LYASE Hydroxymethylglutaryl-coenzyme A lyase active site. SVAGLGGCPY

Chain	Residue	Details
A	SER233-TYR242

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10115

Chain	Residue	Details
A	CYS240

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG15

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|Ref.4

Chain	Residue	Details
A	ASP16
A	HIS207
A	HIS209
A	ASN249

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