2FRS

Crystal structure of the f15w mutant of apo-cellular retinoic acid binding protein type ii at 1.51 angstroms resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001972	molecular_function	retinoic acid binding
A	0005501	molecular_function	retinoid binding
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007165	biological_process	signal transduction
A	0008289	molecular_function	lipid binding
A	0008544	biological_process	epidermis development
A	0015908	biological_process	fatty acid transport
A	0016918	molecular_function	retinal binding
A	0019841	molecular_function	retinol binding
A	0030332	molecular_function	cyclin binding
A	0035115	biological_process	embryonic forelimb morphogenesis
A	0042573	biological_process	retinoic acid metabolic process
A	0048672	biological_process	positive regulation of collateral sprouting
A	0070062	cellular_component	extracellular exosome
B	0001972	molecular_function	retinoic acid binding
B	0005501	molecular_function	retinoid binding
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0007165	biological_process	signal transduction
B	0008289	molecular_function	lipid binding
B	0008544	biological_process	epidermis development
B	0015908	biological_process	fatty acid transport
B	0016918	molecular_function	retinal binding
B	0019841	molecular_function	retinol binding
B	0030332	molecular_function	cyclin binding
B	0035115	biological_process	embryonic forelimb morphogenesis
B	0042573	biological_process	retinoic acid metabolic process
B	0048672	biological_process	positive regulation of collateral sprouting
B	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 501

Chain	Residue
A	GLN74
A	THR75
A	NA503
A	HOH700

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 502

Chain	Residue
A	PRO105
A	THR107
A	HOH716

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 503

Chain	Residue
A	NA501
A	HOH698
A	HOH700
A	HOH715
A	THR75
A	VAL76

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 504

Chain	Residue
A	ASN2
A	SER4
A	LYS20
A	LEU22
A	GLY23
A	ARG136
A	HOH573

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16979656","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FR3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"21998312","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Motif: {"description":"Nuclear localization signal"}

Chain

Residue

Details

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