Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 600 |
| Chain | Residue |
| A | VAL156 |
| A | ALA177 |
| A | GLU178 |
| A | ARG201 |
| A | HOH688 |
| A | HOH720 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | HOH685 |
| A | HOH722 |
| A | GLY18 |
| A | LYS20 |
| A | SER50 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| B | VAL156 |
| B | ALA177 |
| B | GLU178 |
| B | ARG201 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | THR17 |
| B | GLY18 |
| B | LYS20 |
| B | SER50 |
| B | HOH666 |
| B | HOH671 |
| B | HOH723 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 604 |
| Chain | Residue |
| C | ALA177 |
| C | GLU178 |
| C | ARG201 |
| C | HOH706 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 605 |
| Chain | Residue |
| C | GLY18 |
| C | LYS20 |
| C | SER50 |
| C | HOH675 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 606 |
| Chain | Residue |
| D | VAL156 |
| D | ALA177 |
| D | GLU178 |
| D | ARG201 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 607 |
| Chain | Residue |
| D | THR17 |
| D | GLY18 |
| D | LYS20 |
| D | SER50 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | GLU77 |
| A | TYR78 |
| A | ASN81 |
| A | ASN82 |
| A | HOH643 |
| A | HOH697 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR CHAIN E OF ACE-LEU-LEU-ARGININAL (LEUPEPTIN) |
| Chain | Residue |
| A | GLN22 |
| A | GLY26 |
| A | SER27 |
| A | CYS28 |
| A | TRP29 |
| A | CYS67 |
| A | GLN68 |
| A | GLY69 |
| A | GLY70 |
| A | LEU71 |
| A | ALA141 |
| A | LEU165 |
| A | ASP166 |
| B | SER109 |
| E | HOH117 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR CHAIN F OF ACE-LEU-LEU-ARGININAL (LEUPEPTIN) |
| Chain | Residue |
| A | ALA106 |
| A | PRO110 |
| A | HOH745 |
| B | GLN22 |
| B | GLY26 |
| B | CYS28 |
| B | TRP29 |
| B | CYS67 |
| B | GLN68 |
| B | GLY69 |
| B | GLY70 |
| B | LEU71 |
| B | MET72 |
| B | ALA141 |
| B | ASP166 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR CHAIN G OF ACE-LEU-LEU-ARGININAL (LEUPEPTIN) |
| Chain | Residue |
| C | GLN22 |
| C | GLY26 |
| C | SER27 |
| C | CYS28 |
| C | TRP29 |
| C | CYS67 |
| C | GLN68 |
| C | GLY69 |
| C | GLY70 |
| C | LEU71 |
| C | MET72 |
| C | ALA141 |
| C | ASP166 |
| C | HOH703 |
| D | ALA106 |
| site_id | BC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR CHAIN H OF ACE-LEU-LEU-ARGININAL (LEUPEPTIN) |
| Chain | Residue |
| D | MET72 |
| D | ALA141 |
| D | ASP166 |
| D | HIS167 |
| D | HOH622 |
| H | HOH481 |
| C | ALA106 |
| C | PRO110 |
| C | HOH649 |
| D | GLN22 |
| D | GLY26 |
| D | CYS28 |
| D | TRP29 |
| D | CYS67 |
| D | GLY69 |
| D | GLY70 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGkCGSCWAfST |
| Chain | Residue | Details |
| A | GLN22-THR33 | |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LDHGVAVVGYG |
| Chain | Residue | Details |
| A | LEU165-GLY175 | |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWTvKNSWgpsWGeqGYIrV |
| Chain | Residue | Details |
| A | TYR183-VAL202 | |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. VEASGKAF |
| Chain | Residue | Details |
| A | VAL142-PHE149 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"16793521","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FO5","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | CYS28 | |
| A | HIS167 | |
| A | ASN188 | |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | GLN22 | |
| B | HIS167 | |
| B | ASN188 | |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| C | GLN22 | |
| C | HIS167 | |
| C | ASN188 | |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| D | GLN22 | |
| D | HIS167 | |
| D | ASN188 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | CYS28 | |
| B | HIS167 | |
| B | ASN188 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| C | CYS28 | |
| C | HIS167 | |
| C | ASN188 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| D | CYS28 | |
| D | HIS167 | |
| D | ASN188 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | GLN22 | |
| A | CYS28 | |
| A | HIS167 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | GLN22 | |
| B | CYS28 | |
| B | HIS167 | |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| C | GLN22 | |
| C | CYS28 | |
| C | HIS167 | |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| D | GLN22 | |
| D | CYS28 | |
| D | HIS167 | |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | GLN22 | |
| A | HIS167 | |
| A | ASN188 | |
