2FMX
An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| A | 0030127 | cellular_component | COPII vesicle coat |
| A | 0032368 | biological_process | regulation of lipid transport |
| A | 0032580 | cellular_component | Golgi cisterna membrane |
| A | 0042953 | biological_process | lipoprotein transport |
| A | 0048208 | biological_process | COPII vesicle coating |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0070971 | cellular_component | endoplasmic reticulum exit site |
| A | 0090110 | biological_process | COPII-coated vesicle cargo loading |
| A | 0140353 | biological_process | lipid export from cell |
| A | 0140785 | molecular_function | amino acid sensor activity |
| A | 1903432 | biological_process | regulation of TORC1 signaling |
| A | 1904262 | biological_process | negative regulation of TORC1 signaling |
| A | 1990253 | biological_process | cellular response to leucine starvation |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| B | 0030127 | cellular_component | COPII vesicle coat |
| B | 0032368 | biological_process | regulation of lipid transport |
| B | 0032580 | cellular_component | Golgi cisterna membrane |
| B | 0042953 | biological_process | lipoprotein transport |
| B | 0048208 | biological_process | COPII vesicle coating |
| B | 0055088 | biological_process | lipid homeostasis |
| B | 0070971 | cellular_component | endoplasmic reticulum exit site |
| B | 0090110 | biological_process | COPII-coated vesicle cargo loading |
| B | 0140353 | biological_process | lipid export from cell |
| B | 0140785 | molecular_function | amino acid sensor activity |
| B | 1903432 | biological_process | regulation of TORC1 signaling |
| B | 1904262 | biological_process | negative regulation of TORC1 signaling |
| B | 1990253 | biological_process | cellular response to leucine starvation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4770 |
| Chain | Residue |
| A | PHE18 |
| A | GLY185 |
| A | TYR186 |
| A | GLY187 |
| A | GLU188 |
| A | ARG191 |
| A | HOH4781 |
| A | HOH4856 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 4771 |
| Chain | Residue |
| B | GLY185 |
| B | TYR186 |
| B | GLY187 |
| B | GLU188 |
| B | ARG191 |
| B | HOH4795 |
| B | PHE18 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 504 |
| Chain | Residue |
| B | THR39 |
| B | GDP2568 |
| B | HOH4773 |
| B | HOH4794 |
| B | HOH4826 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GDP A 2567 |
| Chain | Residue |
| A | ASP34 |
| A | ASN35 |
| A | ALA36 |
| A | GLY37 |
| A | LYS38 |
| A | THR39 |
| A | THR40 |
| A | ASN134 |
| A | LYS135 |
| A | ASP137 |
| A | SER179 |
| A | VAL180 |
| A | LEU181 |
| A | HOH4808 |
| A | HOH4830 |
| A | HOH4845 |
| A | HOH4857 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GDP B 2568 |
| Chain | Residue |
| B | LEU33 |
| B | ASN35 |
| B | ALA36 |
| B | GLY37 |
| B | LYS38 |
| B | THR39 |
| B | THR40 |
| B | ASN134 |
| B | LYS135 |
| B | ASP137 |
| B | ARG138 |
| B | SER179 |
| B | VAL180 |
| B | LEU181 |
| B | MG504 |
| B | HOH4794 |
| B | HOH4826 |
| B | HOH4863 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Mediates recruitment to ER membranes","evidences":[{"source":"PubMed","id":"11739406","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11739406","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F6B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y6B6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9Y6B6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1d8t |
| Chain | Residue | Details |
| A | ASN35 |
