2FMA

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0046914	molecular_function	transition metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1001

Chain	Residue
A	ALA132
A	HIS147
A	GLY169
A	GLU183
A	VAL185
A	HOH2005
A	HOH2010
A	HOH2085
A	HOH2088

---

Functional Information from PROSITE/UniProt

site_id	PS00319
Number of Residues	8
Details	APP_CUBD Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. GVEFVCCP

Chain	Residue	Details
A	GLY181-PRO188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0000269|PubMed:25122912, ECO:0007744|PDB:2FK1

Chain	Residue	Details
A	HIS147
A	HIS151

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01217, ECO:0000269|PubMed:17239395, ECO:0007744|PDB:2FK1

Chain	Residue	Details
A	TYR168

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:8344894

Chain	Residue	Details
A	GLU183
A	CYS186
A	CYS187

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Required for Cu(2+) reduction => ECO:0000255|PROSITE-ProRule:PRU01217

Chain	Residue	Details
A	MET170

---