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2FLL

Ternary complex of human DNA polymerase iota with DNA and dTTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0003684molecular_functiondamaged DNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0006281biological_processDNA repair
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 871
ChainResidue
AASP34
ALEU35
AASP126
AMG872
ATTP875

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 872
ChainResidue
PDOC873
AASP34
AGLU127
AMG871
ATTP875

site_idAC3
Number of Residues21
DetailsBINDING SITE FOR RESIDUE TTP A 875
ChainResidue
AASP34
ALEU35
AASP36
ACYS37
APHE38
ATYR39
AVAL64
ATHR65
ATYR68
AARG71
ALYS77
AASP126
ALYS214
AMG871
AMG872
AHOH903
AHOH908
AHOH923
PDOC873
TDA840
TDG841

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216
ChainResidueDetails
ATHR152

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5
ChainResidueDetails
AGLN59
ALYS60
AVAL151

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N
ChainResidueDetails
AVAL64
AGLY96

227111

PDB entries from 2024-11-06

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