2FLI
The crystal structure of D-ribulose 5-phosphate 3-epimerase from Streptococus pyogenes complexed with D-xylitol 5-phosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| A | 0019323 | biological_process | pentose catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| B | 0019323 | biological_process | pentose catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006098 | biological_process | pentose-phosphate shunt |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| C | 0019323 | biological_process | pentose catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006098 | biological_process | pentose-phosphate shunt |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| D | 0019323 | biological_process | pentose catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0006098 | biological_process | pentose-phosphate shunt |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| E | 0019323 | biological_process | pentose catabolic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0006098 | biological_process | pentose-phosphate shunt |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| F | 0019323 | biological_process | pentose catabolic process |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005975 | biological_process | carbohydrate metabolic process |
| G | 0006098 | biological_process | pentose-phosphate shunt |
| G | 0016853 | molecular_function | isomerase activity |
| G | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| G | 0019323 | biological_process | pentose catabolic process |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005975 | biological_process | carbohydrate metabolic process |
| H | 0006098 | biological_process | pentose-phosphate shunt |
| H | 0016853 | molecular_function | isomerase activity |
| H | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| H | 0019323 | biological_process | pentose catabolic process |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005975 | biological_process | carbohydrate metabolic process |
| I | 0006098 | biological_process | pentose-phosphate shunt |
| I | 0016853 | molecular_function | isomerase activity |
| I | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| I | 0019323 | biological_process | pentose catabolic process |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005975 | biological_process | carbohydrate metabolic process |
| J | 0006098 | biological_process | pentose-phosphate shunt |
| J | 0016853 | molecular_function | isomerase activity |
| J | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| J | 0019323 | biological_process | pentose catabolic process |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0005975 | biological_process | carbohydrate metabolic process |
| K | 0006098 | biological_process | pentose-phosphate shunt |
| K | 0016853 | molecular_function | isomerase activity |
| K | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| K | 0019323 | biological_process | pentose catabolic process |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0004750 | molecular_function | D-ribulose-phosphate 3-epimerase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0005975 | biological_process | carbohydrate metabolic process |
| L | 0006098 | biological_process | pentose-phosphate shunt |
| L | 0016853 | molecular_function | isomerase activity |
| L | 0016857 | molecular_function | racemase and epimerase activity, acting on carbohydrates and derivatives |
| L | 0019323 | biological_process | pentose catabolic process |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1981 |
| Chain | Residue |
| A | HIS34 |
| A | ASP36 |
| A | HIS67 |
| A | ASP176 |
| A | DX51901 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 1982 |
| Chain | Residue |
| B | DX51902 |
| B | HIS34 |
| B | ASP36 |
| B | HIS67 |
| B | ASP176 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 1983 |
| Chain | Residue |
| C | HIS34 |
| C | ASP36 |
| C | HIS67 |
| C | ASP176 |
| C | DX51903 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 1984 |
| Chain | Residue |
| D | HIS34 |
| D | ASP36 |
| D | HIS67 |
| D | ASP176 |
| D | DX51904 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN E 1985 |
| Chain | Residue |
| E | HIS34 |
| E | ASP36 |
| E | HIS67 |
| E | ASP176 |
| E | DX51905 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN F 1986 |
| Chain | Residue |
| F | HIS34 |
| F | ASP36 |
| F | HIS67 |
| F | ASP176 |
| F | DX51906 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN G 1991 |
| Chain | Residue |
| G | HIS34 |
| G | ASP36 |
| G | HIS67 |
| G | ASP176 |
| G | DX51911 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN H 1992 |
| Chain | Residue |
| H | HIS34 |
| H | ASP36 |
| H | HIS67 |
| H | ASP176 |
| H | DX51912 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN I 1993 |
| Chain | Residue |
| I | HIS34 |
| I | ASP36 |
| I | HIS67 |
| I | ASP176 |
| I | DX51913 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN J 1994 |
| Chain | Residue |
| J | HIS34 |
| J | ASP36 |
| J | HIS67 |
| J | ASP176 |
| J | DX51914 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN K 1995 |
| Chain | Residue |
| K | HIS34 |
| K | ASP36 |
| K | HIS67 |
| K | ASP176 |
| K | DX51915 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN L 1996 |
| Chain | Residue |
| L | HIS34 |
| L | ASP36 |
| L | HIS67 |
| L | ASP176 |
| L | DX51916 |
| site_id | BC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE DX5 A 1901 |
| Chain | Residue |
| A | SER9 |
| A | LEU11 |
| A | HIS34 |
| A | ASP36 |
| A | HIS67 |
| A | MET69 |
| A | PRO142 |
| A | GLY143 |
| A | PHE144 |
| A | GLY145 |
| A | GLY146 |
| A | ASP176 |
| A | GLY177 |
| A | GLY178 |
| A | ALA197 |
| A | GLY198 |
| A | SER199 |
| A | ZN1981 |
| A | HOH1991 |
| A | HOH2020 |
| A | HOH2027 |
| A | HOH2035 |
| A | HOH2039 |
| site_id | BC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE DX5 B 1902 |
| Chain | Residue |
| B | HOH1987 |
| B | HOH1994 |
| B | HOH2001 |
| B | HOH2002 |
| B | HOH2024 |
| B | SER9 |
| B | LEU11 |
| B | HIS34 |
| B | ASP36 |
| B | MET69 |
| B | PRO142 |
| B | GLY143 |
| B | PHE144 |
| B | GLY145 |
| B | GLY146 |
| B | ASP176 |
| B | GLY177 |
| B | GLY178 |
| B | GLY198 |
| B | SER199 |
| B | ZN1982 |
| site_id | BC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE DX5 C 1903 |
| Chain | Residue |
| C | SER9 |
| C | LEU11 |
| C | HIS34 |
| C | ASP36 |
| C | MET38 |
| C | HIS67 |
| C | MET69 |
| C | PRO142 |
| C | GLY143 |
| C | PHE144 |
| C | GLY145 |
| C | GLY146 |
| C | ASP176 |
| C | GLY177 |
| C | GLY178 |
| C | ALA197 |
| C | GLY198 |
| C | SER199 |
| C | ZN1983 |
| C | HOH1990 |
| C | HOH1994 |
| C | HOH1995 |
| C | HOH2036 |
| C | HOH2041 |
| site_id | BC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE DX5 D 1904 |
| Chain | Residue |
| D | SER9 |
| D | LEU11 |
| D | HIS34 |
| D | ASP36 |
| D | MET69 |
| D | PRO142 |
| D | GLY143 |
| D | PHE144 |
| D | GLY145 |
| D | GLY146 |
| D | ASP176 |
| D | GLY177 |
| D | GLY178 |
| D | VAL196 |
| D | ALA197 |
| D | GLY198 |
| D | SER199 |
| D | ZN1984 |
| D | HOH1993 |
| D | HOH2003 |
| D | HOH2005 |
| D | HOH2028 |
| site_id | BC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE DX5 E 1905 |
| Chain | Residue |
| E | SER9 |
| E | LEU11 |
| E | HIS34 |
| E | ASP36 |
| E | HIS67 |
| E | MET69 |
| E | PRO142 |
| E | GLY143 |
| E | PHE144 |
| E | GLY145 |
| E | GLY146 |
| E | ASP176 |
| E | GLY177 |
| E | GLY178 |
| E | GLY198 |
| E | SER199 |
| E | ZN1985 |
| E | HOH1997 |
| E | HOH2002 |
| E | HOH2034 |
| E | HOH2046 |
| site_id | BC9 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE DX5 F 1906 |
| Chain | Residue |
| F | SER9 |
| F | LEU11 |
| F | HIS34 |
| F | ASP36 |
| F | MET38 |
| F | MET69 |
| F | PRO142 |
| F | GLY143 |
| F | PHE144 |
| F | GLY145 |
| F | GLY146 |
| F | ASP176 |
| F | GLY177 |
| F | GLY178 |
| F | ALA197 |
| F | GLY198 |
| F | SER199 |
| F | ZN1986 |
| F | HOH1993 |
| F | HOH2002 |
| F | HOH2016 |
| F | HOH2031 |
| site_id | CC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE DX5 G 1911 |
| Chain | Residue |
| G | SER9 |
| G | LEU11 |
| G | HIS34 |
| G | ASP36 |
| G | MET38 |
| G | MET69 |
| G | PRO142 |
| G | GLY143 |
| G | PHE144 |
| G | GLY145 |
| G | GLY146 |
| G | ASP176 |
| G | GLY177 |
| G | GLY178 |
| G | GLY198 |
| G | SER199 |
| G | ZN1991 |
| G | HOH1992 |
| G | HOH2023 |
| G | HOH2033 |
| G | HOH2042 |
| site_id | CC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE DX5 H 1912 |
| Chain | Residue |
| H | SER9 |
| H | LEU11 |
| H | HIS34 |
| H | ASP36 |
| H | MET38 |
| H | HIS67 |
| H | MET69 |
| H | PRO142 |
| H | GLY143 |
| H | PHE144 |
| H | GLY145 |
| H | GLY146 |
| H | ASP176 |
| H | GLY177 |
| H | GLY178 |
| H | ALA197 |
| H | GLY198 |
| H | SER199 |
| H | ZN1992 |
| H | HOH1993 |
| H | HOH1998 |
| H | HOH2003 |
| H | HOH2007 |
| H | HOH2040 |
| site_id | CC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE DX5 I 1913 |
| Chain | Residue |
| I | SER9 |
| I | LEU11 |
| I | ASP36 |
| I | PRO142 |
| I | GLY143 |
| I | PHE144 |
| I | GLY145 |
| I | GLY146 |
| I | ASP176 |
| I | GLY177 |
| I | GLY178 |
| I | GLY198 |
| I | SER199 |
| I | ZN1993 |
| I | HOH2000 |
| I | HOH2003 |
| I | HOH2004 |
| I | HOH2026 |
| site_id | CC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE DX5 J 1914 |
| Chain | Residue |
| J | SER9 |
| J | LEU11 |
| J | HIS34 |
| J | ASP36 |
| J | HIS67 |
| J | MET69 |
| J | PRO142 |
| J | GLY143 |
| J | PHE144 |
| J | GLY145 |
| J | GLY146 |
| J | ASP176 |
| J | GLY177 |
| J | GLY178 |
| J | ALA197 |
| J | GLY198 |
| J | SER199 |
| J | ZN1994 |
| J | HOH1997 |
| J | HOH2000 |
| J | HOH2015 |
| J | HOH2023 |
| J | HOH2074 |
| site_id | CC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE DX5 K 1915 |
| Chain | Residue |
| K | SER9 |
| K | LEU11 |
| K | HIS34 |
| K | ASP36 |
| K | MET69 |
| K | PRO142 |
| K | GLY143 |
| K | PHE144 |
| K | GLY145 |
| K | GLY146 |
| K | ASP176 |
| K | GLY177 |
| K | GLY178 |
| K | GLY198 |
| K | SER199 |
| K | ZN1995 |
| K | HOH2005 |
| K | HOH2015 |
| K | HOH2037 |
| K | HOH2052 |
| site_id | CC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE DX5 L 1916 |
| Chain | Residue |
| L | SER9 |
| L | LEU11 |
| L | ASP36 |
| L | MET69 |
| L | PRO142 |
| L | GLY143 |
| L | PHE144 |
| L | GLY145 |
| L | GLY146 |
| L | ASP176 |
| L | GLY177 |
| L | GLY178 |
| L | ALA197 |
| L | GLY198 |
| L | SER199 |
| L | ZN1996 |
| L | HOH2009 |
| L | HOH2016 |
| L | HOH2047 |
Functional Information from PROSITE/UniProt
| site_id | PS01085 |
| Number of Residues | 15 |
| Details | RIBUL_P_3_EPIMER_1 Ribulose-phosphate 3-epimerase family signature 1. VHIDImDgqFVpNiS |
| Chain | Residue | Details |
| A | VAL33-SER47 |
| site_id | PS01086 |
| Number of Residues | 23 |
| Details | RIBUL_P_3_EPIMER_2 Ribulose-phosphate 3-epimerase family signature 2. VlIMTVnPgfgGQaFipecleKV |
| Chain | Residue | Details |
| A | VAL135-VAL157 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| A | HIS34 | |
| A | HIS67 | |
| A | ASP176 | |
| A | ASP36 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| J | HIS34 | |
| J | HIS67 | |
| J | ASP176 | |
| J | ASP36 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| K | HIS34 | |
| K | HIS67 | |
| K | ASP176 | |
| K | ASP36 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| L | HIS34 | |
| L | HIS67 | |
| L | ASP176 | |
| L | ASP36 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| B | HIS34 | |
| B | HIS67 | |
| B | ASP176 | |
| B | ASP36 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| C | HIS34 | |
| C | HIS67 | |
| C | ASP176 | |
| C | ASP36 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| D | HIS34 | |
| D | HIS67 | |
| D | ASP176 | |
| D | ASP36 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| E | HIS34 | |
| E | HIS67 | |
| E | ASP176 | |
| E | ASP36 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| F | HIS34 | |
| F | HIS67 | |
| F | ASP176 | |
| F | ASP36 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| G | HIS34 | |
| G | HIS67 | |
| G | ASP176 | |
| G | ASP36 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| H | HIS34 | |
| H | HIS67 | |
| H | ASP176 | |
| H | ASP36 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rpx |
| Chain | Residue | Details |
| I | HIS34 | |
| I | HIS67 | |
| I | ASP176 | |
| I | ASP36 |
