2FJ9
High resolution crystal structure of the unliganded human ACBP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000062 | molecular_function | fatty-acyl-CoA binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0030156 | molecular_function | benzodiazepine receptor binding |
| A | 0032994 | cellular_component | protein-lipid complex |
| A | 0036042 | molecular_function | long-chain fatty acyl-CoA binding |
| A | 0036151 | biological_process | phosphatidylcholine acyl-chain remodeling |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 2001140 | biological_process | positive regulation of phospholipid transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PB A 1 |
| Chain | Residue |
| A | GLU61 |
| A | ASP69 |
| A | CL89 |
| A | HOH1101 |
| A | HOH1156 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 88 |
| Chain | Residue |
| A | HOH1277 |
| A | HOH1277 |
| A | GLU11 |
| A | GLU11 |
| A | HIS15 |
| A | HIS15 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 89 |
| Chain | Residue |
| A | PB1 |
| A | GLU61 |
| A | ASP69 |
| A | HOH1034 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 90 |
| Chain | Residue |
| A | ASP22 |
| A | GLU43 |
Functional Information from PROSITE/UniProt
| site_id | PS00880 |
| Number of Residues | 19 |
| Details | ACB_1 Acyl-CoA-binding (ACB) domain signature. PSdEeMlfIYGhYKQATvG |
| Chain | Residue | Details |
| A | PRO20-GLY38 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 85 |
| Details | Domain: {"description":"ACB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00573","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17044054","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CB8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"3525533","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P31786","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P31786","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
