Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2FIX

Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitiors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0005986	biological_process	sucrose biosynthetic process
A	0006000	biological_process	fructose metabolic process
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006111	biological_process	regulation of gluconeogenesis
A	0016208	molecular_function	AMP binding
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030308	biological_process	negative regulation of cell growth
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0031667	biological_process	response to nutrient levels
A	0032869	biological_process	cellular response to insulin stimulus
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0045820	biological_process	negative regulation of glycolytic process
A	0046580	biological_process	negative regulation of Ras protein signal transduction
A	0046872	molecular_function	metal ion binding
A	0048029	molecular_function	monosaccharide binding
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070062	cellular_component	extracellular exosome
A	0071286	biological_process	cellular response to magnesium ion
A	0071320	biological_process	cellular response to cAMP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071477	biological_process	cellular hypotonic salinity response
A	0097403	biological_process	cellular response to raffinose
A	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0005986	biological_process	sucrose biosynthetic process
D	0006000	biological_process	fructose metabolic process
D	0006002	biological_process	fructose 6-phosphate metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006111	biological_process	regulation of gluconeogenesis
D	0016208	molecular_function	AMP binding
D	0016311	biological_process	dephosphorylation
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030308	biological_process	negative regulation of cell growth
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0031667	biological_process	response to nutrient levels
D	0032869	biological_process	cellular response to insulin stimulus
D	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0045820	biological_process	negative regulation of glycolytic process
D	0046580	biological_process	negative regulation of Ras protein signal transduction
D	0046872	molecular_function	metal ion binding
D	0048029	molecular_function	monosaccharide binding
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0070062	cellular_component	extracellular exosome
D	0071286	biological_process	cellular response to magnesium ion
D	0071320	biological_process	cellular response to cAMP
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071475	biological_process	cellular hyperosmotic salinity response
D	0071477	biological_process	cellular hypotonic salinity response
D	0097403	biological_process	cellular response to raffinose
D	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0005986	biological_process	sucrose biosynthetic process
H	0006000	biological_process	fructose metabolic process
H	0006002	biological_process	fructose 6-phosphate metabolic process
H	0006094	biological_process	gluconeogenesis
H	0006111	biological_process	regulation of gluconeogenesis
H	0016208	molecular_function	AMP binding
H	0016311	biological_process	dephosphorylation
H	0016787	molecular_function	hydrolase activity
H	0016791	molecular_function	phosphatase activity
H	0030308	biological_process	negative regulation of cell growth
H	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
H	0031667	biological_process	response to nutrient levels
H	0032869	biological_process	cellular response to insulin stimulus
H	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
H	0042578	molecular_function	phosphoric ester hydrolase activity
H	0042802	molecular_function	identical protein binding
H	0045820	biological_process	negative regulation of glycolytic process
H	0046580	biological_process	negative regulation of Ras protein signal transduction
H	0046872	molecular_function	metal ion binding
H	0048029	molecular_function	monosaccharide binding
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0070062	cellular_component	extracellular exosome
H	0071286	biological_process	cellular response to magnesium ion
H	0071320	biological_process	cellular response to cAMP
H	0071466	biological_process	cellular response to xenobiotic stimulus
H	0071475	biological_process	cellular hyperosmotic salinity response
H	0071477	biological_process	cellular hypotonic salinity response
H	0097403	biological_process	cellular response to raffinose
H	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0005515	molecular_function	protein binding
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005975	biological_process	carbohydrate metabolic process
L	0005986	biological_process	sucrose biosynthetic process
L	0006000	biological_process	fructose metabolic process
L	0006002	biological_process	fructose 6-phosphate metabolic process
L	0006094	biological_process	gluconeogenesis
L	0006111	biological_process	regulation of gluconeogenesis
L	0016208	molecular_function	AMP binding
L	0016311	biological_process	dephosphorylation
L	0016787	molecular_function	hydrolase activity
L	0016791	molecular_function	phosphatase activity
L	0030308	biological_process	negative regulation of cell growth
L	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
L	0031667	biological_process	response to nutrient levels
L	0032869	biological_process	cellular response to insulin stimulus
L	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
L	0042578	molecular_function	phosphoric ester hydrolase activity
L	0042802	molecular_function	identical protein binding
L	0045820	biological_process	negative regulation of glycolytic process
L	0046580	biological_process	negative regulation of Ras protein signal transduction
L	0046872	molecular_function	metal ion binding
L	0048029	molecular_function	monosaccharide binding
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0070062	cellular_component	extracellular exosome
L	0071286	biological_process	cellular response to magnesium ion
L	0071320	biological_process	cellular response to cAMP
L	0071466	biological_process	cellular response to xenobiotic stimulus
L	0071475	biological_process	cellular hyperosmotic salinity response
L	0071477	biological_process	cellular hypotonic salinity response
L	0097403	biological_process	cellular response to raffinose
L	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 870 A 701

Chain	Residue
A	VAL17
A	MET177
L	GLY26
L	THR27
L	GLY28
L	THR31
L	8701001
A	MET18
A	GLY21
A	ARG22
A	ALA24
A	ARG25
A	GLY26
A	LEU30
A	THR31

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 870 D 801

Chain	Residue
D	VAL17
D	MET18
D	GLU20
D	GLY21
D	ALA24
D	ARG25
D	GLY26
D	THR27
D	GLY28
D	GLU29
D	LEU30
D	THR31
H	GLY26
H	THR27
H	870901

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 870 H 901

Chain	Residue
D	GLY26
D	THR27
D	870801
H	VAL17
H	MET18
H	GLY21
H	ALA24
H	ARG25
H	GLY26
H	THR27
H	GLY28
H	GLU29
H	LEU30
H	THR31
H	MET177

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 870 L 1001

Chain	Residue
A	GLY26
A	THR27
A	THR31
A	870701
L	VAL17
L	GLY21
L	ALA24
L	ARG25
L	GLY26
L	THR27
L	GLY28
L	LEU30
L	THR31
L	MET177

Functional Information from PROSITE/UniProt

site_id	PS00124
Number of Residues	13
Details	FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA

Chain	Residue	Details
A	GLY273-ALA285

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:7809062, ECO:0007744\|PDB:1FTA

Chain	Residue	Details
A	VAL17
H	THR27
H	LYS112
H	ARG140
L	VAL17
L	THR27
L	LYS112
L	ARG140
A	THR27
A	LYS112
A	ARG140
D	VAL17
D	THR27
D	LYS112
D	ARG140
H	VAL17

site_id	SWS_FT_FI2
Number of Residues	28
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00636

Chain	Residue	Details
A	ASP68
D	LEU120
D	ASN212
D	ARG243
D	TYR264
D	LYS274
H	ASP68
H	GLU97
H	LEU120
H	ASN212
H	ARG243
A	GLU97
H	TYR264
H	LYS274
L	ASP68
L	GLU97
L	LEU120
L	ASN212
L	ARG243
L	TYR264
L	LYS274
A	LEU120
A	ASN212
A	ARG243
A	TYR264
A	LYS274
D	ASP68
D	GLU97

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744\|PDB:2FHY

Chain	Residue	Details
A	ASP118
L	ASP118
L	ASP121
L	GLU280
A	ASP121
A	GLU280
D	ASP118
D	ASP121
D	GLU280
H	ASP118
H	ASP121
H	GLU280

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000250\|UniProtKB:P00637

Chain	Residue	Details
A	ALA1
D	ALA1
H	ALA1
L	ALA1

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9QXD6

Chain	Residue	Details
A	LYS150
D	LYS150
H	LYS150
L	LYS150

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q9QXD6

Chain	Residue	Details
A	TYR215
A	TYR244
D	TYR215
D	TYR244
H	TYR215
H	TYR244
L	TYR215
L	TYR244

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	TYR264
D	TYR264
H	TYR264
L	TYR264

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
A	GLU98
A	ASP74

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
D	GLU98
D	ASP74

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
H	GLU98
H	ASP74

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
L	GLU98
L	ASP74

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)