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2FH7

Crystal structure of the phosphatase domains of human PTP SIGMA

Functional Information from GO Data
ChainGOidnamespacecontents
A0004725molecular_functionprotein tyrosine phosphatase activity
A0006470biological_processprotein dephosphorylation
A0016311biological_processdephosphorylation
Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG
ChainResidueDetails
AVAL1587-GLY1597
AVAL1878-GLY1888

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues255
DetailsDomain: {"description":"Tyrosine-protein phosphatase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsActive site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PubMed","id":"23820885","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsActive site: {"description":"Phosphocysteine intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues6
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
AARG1595
AHIS1588
ACYS1589
ATHR1596
AGLU1495
AASP1557

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
AARG1595
ACYS1589
AASP1557

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
ACYS1880
AARG1886
AGLU1846

site_idCSA4
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
AARG1595
ACYS1589
AASP1557
ATHR1596

site_idCSA5
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
ACYS1880
AARG1886
AGLU1846
ATHR1887

246704

PDB entries from 2025-12-24

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