2FFV

Human ppGalNAcT-2 complexed with manganese and UDP

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 5600

Chain	Residue
A	ASP224
A	HIS226
A	HIS359
A	UDP5601

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 9600

Chain	Residue
B	ASP224
B	HIS226
B	HIS359
B	UDP9601

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE UDP A 5601

Chain	Residue
A	PHE144
A	HIS145
A	ASP176
A	ARG201
A	GLY203
A	LEU204
A	SER207
A	ASP224
A	HIS226
A	VAL330
A	HIS359
A	ARG362
A	HIS365
A	MN5600
A	THR143

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UDP B 9601

Chain	Residue
B	THR143
B	PHE144
B	ASP176
B	ARG201
B	GLY203
B	LEU204
B	ASP224
B	HIS226
B	VAL330
B	HIS359
B	ARG362
B	HIS365
B	MN9600

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	210
Details	Region: {"description":"Catalytic subdomain A"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	124
Details	Region: {"description":"Catalytic subdomain B"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16434399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24954443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25939779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16434399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24954443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25939779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16434399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24954443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25939779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EGS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Not glycosylated"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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