2FF0

Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit Promoter

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	CYS13
A	CYS16
A	CYS30
A	CYS33

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	CYS49
A	SER52
A	CYS55
A	CYS65
A	CYS68

---

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CpvCg.Dkvsgy.HYglltCesCkgFFkR

Chain	Residue	Details
A	CYS13-ARG39

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	75
Details	DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	ASP10-ALA85

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	CYS13-CYS33
A	CYS49-CYS73

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q13285

Chain	Residue	Details
A	LYS34
A	LYS38
A	LYS72

---