2FD8

Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006307	biological_process	DNA alkylation repair
A	0006974	biological_process	DNA damage response
A	0008198	molecular_function	ferrous iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0035513	biological_process	oxidative RNA demethylation
A	0035515	molecular_function	oxidative RNA demethylase activity
A	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0070989	biological_process	oxidative demethylation
A	0072702	biological_process	response to methyl methanesulfonate

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 300

Chain	Residue
A	HIS131
A	ASP133
A	HIS187
A	AKG400
A	HOH671

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AKG A 400

Chain	Residue
A	ASP133
A	HIS187
A	ILE189
A	ARG204
A	ASN206
A	ARG210
A	FE2300
A	HOH619
A	HOH671
B	MA7502
A	LEU118
A	ASN120
A	TYR122
A	HIS131

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16482161","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20084272","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16482161","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---