2FC0

WRN exonuclease, Mn dGMP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0008408	molecular_function	3'-5' exonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 237

Chain	Residue
A	ASP82
A	GLU84
A	ASP216
A	HOH257
A	HOH369
A	HOH425

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 238

Chain	Residue
A	HOH424
A	HOH425
A	HOH427
A	ASP82
A	HOH248
A	HOH374

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DGP A 239

Chain	Residue
A	TYR55
A	TYR57
A	TRP145
A	PHE203
A	PRO204
A	LYS210
A	HOH240
A	HOH331
A	HOH377
A	HOH407

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16622405, ECO:0007744|PDB:2FBV, ECO:0007744|PDB:2FBX, ECO:0007744|PDB:2FC0

Chain	Residue	Details
A	ASP82
A	GLU84
A	ASP216

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Interaction with DNA => ECO:0000305|PubMed:20159463

Chain	Residue	Details
A	TRP145

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS154

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