2FC0

WRN exonuclease, Mn dGMP complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0008408	molecular_function	3'-5' exonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 237

Chain	Residue
A	ASP82
A	GLU84
A	ASP216
A	HOH257
A	HOH369
A	HOH425

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 238

Chain	Residue
A	HOH424
A	HOH425
A	HOH427
A	ASP82
A	HOH248
A	HOH374

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DGP A 239

Chain	Residue
A	TYR55
A	TYR57
A	TRP145
A	PHE203
A	PRO204
A	LYS210
A	HOH240
A	HOH331
A	HOH377
A	HOH407

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	168
Details	Domain: {"description":"3'-5' exonuclease","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11863428","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16622405","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FC0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"20159463","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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