2FAH
The structure of mitochondrial PEPCK, Complex with Mn and GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| A | 0004613 | molecular_function | phosphoenolpyruvate carboxykinase (GTP) activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0017076 | molecular_function | purine nucleotide binding |
| B | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| B | 0004613 | molecular_function | phosphoenolpyruvate carboxykinase (GTP) activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0017076 | molecular_function | purine nucleotide binding |
| C | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| C | 0004613 | molecular_function | phosphoenolpyruvate carboxykinase (GTP) activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0017076 | molecular_function | purine nucleotide binding |
| D | 0004611 | molecular_function | phosphoenolpyruvate carboxykinase activity |
| D | 0004613 | molecular_function | phosphoenolpyruvate carboxykinase (GTP) activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0017076 | molecular_function | purine nucleotide binding |
Functional Information from PROSITE/UniProt
| site_id | PS00505 |
| Number of Residues | 9 |
| Details | PEPCK_GTP Phosphoenolpyruvate carboxykinase (GTP) signature. FPSACGKTN |
| Chain | Residue | Details |
| A | PHE303-ASN311 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16819824, ECO:0007744|PDB:2QZY |
| Chain | Residue | Details |
| A | ARG105 | |
| D | ARG105 | |
| D | ASN422 | |
| D | ARG424 | |
| A | ASN422 | |
| A | ARG424 | |
| B | ARG105 | |
| B | ASN422 | |
| B | ARG424 | |
| C | ARG105 | |
| C | ASN422 | |
| C | ARG424 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0007744|PDB:2QZY |
| Chain | Residue | Details |
| A | GLY256 | |
| B | GLY256 | |
| C | GLY256 | |
| D | GLY256 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16819824, ECO:0007744|PDB:2FAF, ECO:0007744|PDB:2FAH, ECO:0007744|PDB:2QZY |
| Chain | Residue | Details |
| A | LYS263 | |
| D | LYS263 | |
| D | HIS283 | |
| D | ASP330 | |
| A | HIS283 | |
| A | ASP330 | |
| B | LYS263 | |
| B | HIS283 | |
| B | ASP330 | |
| C | LYS263 | |
| C | HIS283 | |
| C | ASP330 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16819824, ECO:0007744|PDB:2FAH |
| Chain | Residue | Details |
| A | ALA306 | |
| A | PHE549 | |
| A | ASN552 | |
| B | ALA306 | |
| B | GLY308 | |
| B | LYS309 | |
| B | THR310 | |
| B | ASN311 | |
| B | PRO356 | |
| B | ARG455 | |
| B | TRP535 | |
| A | GLY308 | |
| B | PHE544 | |
| B | PHE549 | |
| B | ASN552 | |
| C | ALA306 | |
| C | GLY308 | |
| C | LYS309 | |
| C | THR310 | |
| C | ASN311 | |
| C | PRO356 | |
| C | ARG455 | |
| A | LYS309 | |
| C | TRP535 | |
| C | PHE544 | |
| C | PHE549 | |
| C | ASN552 | |
| D | ALA306 | |
| D | GLY308 | |
| D | LYS309 | |
| D | THR310 | |
| D | ASN311 | |
| D | PRO356 | |
| A | THR310 | |
| D | ARG455 | |
| D | TRP535 | |
| D | PHE544 | |
| D | PHE549 | |
| D | ASN552 | |
| A | ASN311 | |
| A | PRO356 | |
| A | ARG455 | |
| A | TRP535 | |
| A | PHE544 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16819824, ECO:0007744|PDB:2FAF |
| Chain | Residue | Details |
| A | CYS307 | |
| B | CYS307 | |
| C | CYS307 | |
| D | CYS307 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| A | LYS309 | |
| A | HIS283 | |
| A | ARG424 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| B | LYS309 | |
| B | HIS283 | |
| B | ARG424 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| C | LYS309 | |
| C | HIS283 | |
| C | ARG424 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| D | LYS309 | |
| D | HIS283 | |
| D | ARG424 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| A | HIS283 | |
| A | ARG424 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| B | HIS283 | |
| B | ARG424 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| C | HIS283 | |
| C | ARG424 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aq2 |
| Chain | Residue | Details |
| D | HIS283 | |
| D | ARG424 |
