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2F8A

Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0001659biological_processtemperature homeostasis
A0001885biological_processendothelial cell development
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004601molecular_functionperoxidase activity
A0004602molecular_functionglutathione peroxidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006641biological_processtriglyceride metabolic process
A0006749biological_processglutathione metabolic process
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0007605biological_processsensory perception of sound
A0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
A0009410biological_processresponse to xenobiotic stimulus
A0009609biological_processresponse to symbiotic bacterium
A0009611biological_processresponse to wounding
A0009636biological_processresponse to toxic substance
A0009650biological_processUV protection
A0009725biological_processresponse to hormone
A0009749biological_processresponse to glucose
A0010269biological_processresponse to selenium ion
A0010332biological_processresponse to gamma radiation
A0014070biological_processresponse to organic cyclic compound
A0014902biological_processmyotube differentiation
A0017124molecular_functionSH3 domain binding
A0019369biological_processarachidonic acid metabolic process
A0019372biological_processlipoxygenase pathway
A0032355biological_processresponse to estradiol
A0033194biological_processresponse to hydroperoxide
A0033197biological_processresponse to vitamin E
A0033599biological_processregulation of mammary gland epithelial cell proliferation
A0034599biological_processcellular response to oxidative stress
A0035094biological_processresponse to nicotine
A0040029biological_processepigenetic regulation of gene expression
A0042311biological_processvasodilation
A0042542biological_processresponse to hydrogen peroxide
A0042744biological_processhydrogen peroxide catabolic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043403biological_processskeletal muscle tissue regeneration
A0043534biological_processblood vessel endothelial cell migration
A0045444biological_processfat cell differentiation
A0045445biological_processmyoblast differentiation
A0045454biological_processcell redox homeostasis
A0047066molecular_functionphospholipid-hydroperoxide glutathione peroxidase activity
A0048144biological_processfibroblast proliferation
A0048741biological_processskeletal muscle fiber development
A0051402biological_processneuron apoptotic process
A0051450biological_processmyoblast proliferation
A0051593biological_processresponse to folic acid
A0051702biological_processbiological process involved in interaction with symbiont
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060047biological_processheart contraction
A0060055biological_processangiogenesis involved in wound healing
A0061136biological_processregulation of proteasomal protein catabolic process
A0071333biological_processcellular response to glucose stimulus
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097413cellular_componentLewy body
A0098869biological_processcellular oxidant detoxification
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902905biological_processpositive regulation of supramolecular fiber organization
B0000302biological_processresponse to reactive oxygen species
B0001659biological_processtemperature homeostasis
B0001885biological_processendothelial cell development
B0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
B0004601molecular_functionperoxidase activity
B0004602molecular_functionglutathione peroxidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006641biological_processtriglyceride metabolic process
B0006749biological_processglutathione metabolic process
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0007605biological_processsensory perception of sound
B0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
B0009410biological_processresponse to xenobiotic stimulus
B0009609biological_processresponse to symbiotic bacterium
B0009611biological_processresponse to wounding
B0009636biological_processresponse to toxic substance
B0009650biological_processUV protection
B0009725biological_processresponse to hormone
B0009749biological_processresponse to glucose
B0010269biological_processresponse to selenium ion
B0010332biological_processresponse to gamma radiation
B0014070biological_processresponse to organic cyclic compound
B0014902biological_processmyotube differentiation
B0017124molecular_functionSH3 domain binding
B0019369biological_processarachidonic acid metabolic process
B0019372biological_processlipoxygenase pathway
B0032355biological_processresponse to estradiol
B0033194biological_processresponse to hydroperoxide
B0033197biological_processresponse to vitamin E
B0033599biological_processregulation of mammary gland epithelial cell proliferation
B0034599biological_processcellular response to oxidative stress
B0035094biological_processresponse to nicotine
B0040029biological_processepigenetic regulation of gene expression
B0042311biological_processvasodilation
B0042542biological_processresponse to hydrogen peroxide
B0042744biological_processhydrogen peroxide catabolic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043403biological_processskeletal muscle tissue regeneration
B0043534biological_processblood vessel endothelial cell migration
B0045444biological_processfat cell differentiation
B0045445biological_processmyoblast differentiation
B0045454biological_processcell redox homeostasis
B0047066molecular_functionphospholipid-hydroperoxide glutathione peroxidase activity
B0048144biological_processfibroblast proliferation
B0048741biological_processskeletal muscle fiber development
B0051402biological_processneuron apoptotic process
B0051450biological_processmyoblast proliferation
B0051593biological_processresponse to folic acid
B0051702biological_processbiological process involved in interaction with symbiont
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0060047biological_processheart contraction
B0060055biological_processangiogenesis involved in wound healing
B0061136biological_processregulation of proteasomal protein catabolic process
B0071333biological_processcellular response to glucose stimulus
B0090201biological_processnegative regulation of release of cytochrome c from mitochondria
B0097413cellular_componentLewy body
B0098869biological_processcellular oxidant detoxification
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1902905biological_processpositive regulation of supramolecular fiber organization
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE MLA A 501
ChainResidue
AMET142
AHOH608
AHOH637
AHOH647
ATHR143
AASP144
ALEU147
ATRP160
AARG179
AHOH547
AHOH567
AHOH600

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE MLA B 502
ChainResidue
BMET142
BTHR143
BASP144
BLEU147
BTRP160
BARG179
BHOH541
BHOH573
BHOH587
BHOH600
BHOH655
BHOH682

Functional Information from PROSITE/UniProt
site_idPS00763
Number of Residues8
DetailsGLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LGFPCNQF
ChainResidueDetails
ALEU72-PHE79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:O70325
ChainResidueDetails
ATHR49
BTHR49

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Subject to oxidation and hydroselenide loss to dehydroalanine => ECO:0000250
ChainResidueDetails
ATHR49
BTHR49

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04041
ChainResidueDetails
AARG34
BARG34

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P11352
ChainResidueDetails
AGLU88
AGLU114
AILE148
BGLU88
BGLU114
BILE148

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1gp1
ChainResidueDetails
AGLN82
ATRP160

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1gp1
ChainResidueDetails
BGLN82
BTRP160

219140

PDB entries from 2024-05-01

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