Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2F2H

Structure of the YicI thiosugar Michaelis complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0030246	molecular_function	carbohydrate binding
A	0042802	molecular_function	identical protein binding
A	0061634	molecular_function	alpha-D-xyloside xylohydrolase
A	0080176	molecular_function	xyloglucan 1,6-alpha-xylosidase activity
B	0003824	molecular_function	catalytic activity
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0005975	biological_process	carbohydrate metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0030246	molecular_function	carbohydrate binding
B	0042802	molecular_function	identical protein binding
B	0061634	molecular_function	alpha-D-xyloside xylohydrolase
B	0080176	molecular_function	xyloglucan 1,6-alpha-xylosidase activity
C	0003824	molecular_function	catalytic activity
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0005975	biological_process	carbohydrate metabolic process
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0030246	molecular_function	carbohydrate binding
C	0042802	molecular_function	identical protein binding
C	0061634	molecular_function	alpha-D-xyloside xylohydrolase
C	0080176	molecular_function	xyloglucan 1,6-alpha-xylosidase activity
D	0003824	molecular_function	catalytic activity
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0005975	biological_process	carbohydrate metabolic process
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0030246	molecular_function	carbohydrate binding
D	0042802	molecular_function	identical protein binding
D	0061634	molecular_function	alpha-D-xyloside xylohydrolase
D	0080176	molecular_function	xyloglucan 1,6-alpha-xylosidase activity
E	0003824	molecular_function	catalytic activity
E	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
E	0005975	biological_process	carbohydrate metabolic process
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0030246	molecular_function	carbohydrate binding
E	0042802	molecular_function	identical protein binding
E	0061634	molecular_function	alpha-D-xyloside xylohydrolase
E	0080176	molecular_function	xyloglucan 1,6-alpha-xylosidase activity
F	0003824	molecular_function	catalytic activity
F	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
F	0005975	biological_process	carbohydrate metabolic process
F	0016787	molecular_function	hydrolase activity
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0030246	molecular_function	carbohydrate binding
F	0042802	molecular_function	identical protein binding
F	0061634	molecular_function	alpha-D-xyloside xylohydrolase
F	0080176	molecular_function	xyloglucan 1,6-alpha-xylosidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 3001

Chain	Residue
F	THR246
F	ARG583
F	HOH3246

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3002

Chain	Residue
D	THR246
D	ARG583
D	HOH3087

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 3003

Chain	Residue
F	VAL681
F	HOH3093
F	HOH3277
F	HOH3315
A	LYS403
F	ARG677
F	TYR680

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 3004

Chain	Residue
E	THR246
E	ARG583
E	HOH3065

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3005

Chain	Residue
C	THR246
C	LYS248
C	ARG583
C	HOH3228

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 3006

Chain	Residue
B	THR246
B	ARG583

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 3007

Chain	Residue
F	ARG333
F	ARG334

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3008

Chain	Residue
A	THR246
A	LYS248
A	ARG583
A	HOH3191

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 3009

Chain	Residue
E	GLU24
E	VAL25
E	ASN96
E	LYS114

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPO B 3010

Chain	Residue
B	HIS640
B	ASP642
B	GLN653
B	HIS654
B	GLY655
B	SER658
B	HOH3282

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPO C 3011

Chain	Residue
C	HIS640
C	ASP642
C	GLN653
C	HIS654
C	GLY655
C	SER658
C	HOH3347

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPO D 3012

Chain	Residue
D	HIS640
D	ASP642
D	GLN652
D	GLN653
D	HIS654
D	GLY655
D	SER658
D	HOH3325

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPO E 3013

Chain	Residue
D	HOH3303
E	HIS640
E	GLN652
E	GLN653
E	HIS654
E	GLY655
E	SER658

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPO F 3014

Chain	Residue
F	HIS640
F	GLN653
F	HIS654
F	GLY655
F	SER658
F	HOH3153

site_id	BC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE XTG A 3015

Chain	Residue
A	ASP185
A	PHE277
A	THR278
A	ASP306
A	CYS307
A	TRP380
A	LYS414
A	ASP416
A	ARG466
A	TRP479
A	ASP482
A	PHE515
A	HIS540
A	SER542
A	HOH3030
A	HOH3033
A	HOH3118
A	HOH3157
B	THR45
B	LEU48
B	ASP49

site_id	BC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE XTG B 3016

Chain	Residue
B	HOH3035
B	HOH3068
C	TRP8
F	LEU48
F	ASP49
F	HOH3224
B	ASP185
B	ASP306
B	TRP380
B	LYS414
B	ASP416
B	ARG466
B	TRP479
B	ASP482
B	PHE515
B	HIS540
B	SER542

site_id	BC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE XTG C 3017

Chain	Residue
C	ASP185
C	PHE277
C	THR278
C	ASP306
C	CYS307
C	TRP380
C	LYS414
C	ASP416
C	PHE417
C	ARG466
C	TRP479
C	ASP482
C	PHE515
C	HIS540
C	SER542
C	LYS543
C	HOH3049
C	HOH3085
C	HOH3189
C	HOH3273
D	THR45
D	ASP49

site_id	BC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE XTG D 3018

Chain	Residue
D	ASP185
D	ASP306
D	LYS414
D	ASP416
D	ARG420
D	ARG466
D	TRP479
D	ASP482
D	PHE515
D	ARG538
D	HIS540
D	LYS543
D	HOH3167
D	HOH3284
E	THR45
E	ASP49
E	HOH3117

site_id	CC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE XTG E 3019

Chain	Residue
C	ASP49
E	ASP185
E	PHE277
E	THR278
E	ASP306
E	TRP380
E	ASP416
E	PHE417
E	ARG466
E	TRP479
E	ASP482
E	PHE515
E	HIS540
E	SER542
E	LYS543
E	HOH3120
E	HOH3153
E	HOH3273
F	TRP8

site_id	CC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE XTG F 3020

Chain	Residue
A	LEU48
A	ASP49
F	ASP185
F	PHE277
F	ASP306
F	TRP380
F	LYS414
F	ASP416
F	ARG466
F	TRP479
F	ASP482
F	PHE515
F	HIS540
F	LYS543
F	HOH3038
F	HOH3052
F	HOH3149
F	HOH3234

site_id	CC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE XTG F 3021

Chain	Residue
A	GLU329
F	TRP267
F	HIS301
F	LYS336
F	ALA337
F	GLY339
F	LEU340
F	ARG677
F	PRO678
F	ASP679
F	HOH3047
F	HOH3062

site_id	CC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL F 3022

Chain	Residue
A	THR455
A	VAL456
F	PRO265
F	ALA266
F	TRP267
F	GLU460
F	TYR574
F	ASP679
F	HOH3273
F	HOH3274

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 3023

Chain	Residue
C	ARG68
C	ASN211
C	GLU238
C	GOL3030
C	HOH3081
C	HOH3218
C	HOH3365

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 3024

Chain	Residue
A	GLN27
A	ASP29
A	VAL92
A	THR93
A	ILE94
A	HOH3308

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 3025

Chain	Residue
B	GLU31
B	PHE58
B	ARG68
B	GLU238
B	GOL3026

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 3026

Chain	Residue
B	ARG68
B	HIS81
B	ASN211
B	GLU238
B	GOL3025
B	HOH3238
B	HOH3285

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 3027

Chain	Residue
B	TRP8
C	ASP482
C	TYR484
C	PHE515
C	HOH3266

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 3028

Chain	Residue
A	GLU31
A	PHE58
A	ARG68
A	GLU238
A	GOL3029
A	HOH3342

site_id	DC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 3029

Chain	Residue
A	ARG68
A	HIS81
A	ASN211
A	GLU238
A	GOL3028
A	HOH3127
A	HOH3137
A	HOH3333

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 3030

Chain	Residue
C	GLU31
C	PHE58
C	ARG68
C	GLU238
C	GOL3023
C	HOH3365

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 3031

Chain	Residue
D	GLU31
D	PHE58
D	ARG68
D	GLU238
D	HOH3318
D	HOH3322

site_id	DC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 3032

Chain	Residue
D	ARG68
D	HIS81
D	LEU84
D	ASN211
D	GLU238
D	HOH3098
D	HOH3145
D	HOH3209

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 3033

Chain	Residue
E	GLU31
E	PHE58
E	ARG68
E	GLU238
E	HOH3191

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL F 3034

Chain	Residue
F	GLU31
F	PHE58
F	ARG68
F	GLU238

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 3035

Chain	Residue
E	ASP482
E	TYR484
E	PHE515
E	GLU516
F	TRP8

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15501829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"evidences":[{"source":"PubMed","id":"15501829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15501829","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)