2F28
Crystal Structure of the Human Sialidase Neu2 Q116E Mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006516 | biological_process | glycoprotein catabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 0052794 | molecular_function | obsolete exo-alpha-(2->3)-sialidase activity |
| A | 0052795 | molecular_function | obsolete exo-alpha-(2->6)-sialidase activity |
| A | 0052796 | molecular_function | obsolete exo-alpha-(2->8)-sialidase activity |
| A | 1902494 | cellular_component | catalytic complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1001 |
| Chain | Residue |
| A | LEU28 |
| A | GLY30 |
| A | GLN31 |
| A | HOH1077 |
| A | HOH1268 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1002 |
| Chain | Residue |
| A | HOH1012 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:22228546 |
| Chain | Residue | Details |
| A | ASP46 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | TYR334 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU355 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG21 | |
| A | ARG41 | |
| A | TYR179 | |
| A | TYR181 | |
| A | GLU218 | |
| A | ARG237 | |
| A | ARG304 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1euu |
| Chain | Residue | Details |
| A | TYR334 | |
| A | GLU218 |
