2F1D
X-Ray Structure of imidazoleglycerol-phosphate dehydratase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| B | 0000105 | biological_process | L-histidine biosynthetic process |
| B | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| C | 0000105 | biological_process | L-histidine biosynthetic process |
| C | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| D | 0000105 | biological_process | L-histidine biosynthetic process |
| D | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| E | 0000105 | biological_process | L-histidine biosynthetic process |
| E | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| F | 0000105 | biological_process | L-histidine biosynthetic process |
| F | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| G | 0000105 | biological_process | L-histidine biosynthetic process |
| G | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| H | 0000105 | biological_process | L-histidine biosynthetic process |
| H | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| I | 0000105 | biological_process | L-histidine biosynthetic process |
| I | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| J | 0000105 | biological_process | L-histidine biosynthetic process |
| J | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| K | 0000105 | biological_process | L-histidine biosynthetic process |
| K | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| L | 0000105 | biological_process | L-histidine biosynthetic process |
| L | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| M | 0000105 | biological_process | L-histidine biosynthetic process |
| M | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| N | 0000105 | biological_process | L-histidine biosynthetic process |
| N | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| O | 0000105 | biological_process | L-histidine biosynthetic process |
| O | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
| P | 0000105 | biological_process | L-histidine biosynthetic process |
| P | 0004424 | molecular_function | imidazoleglycerol-phosphate dehydratase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 300 |
| Chain | Residue |
| A | HIS170 |
| B | HIS73 |
| B | GLU77 |
| B | HIS145 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 301 |
| Chain | Residue |
| A | HIS47 |
| A | HIS169 |
| A | GLU173 |
| B | HIS74 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 398 |
| Chain | Residue |
| A | ARG99 |
| A | LYS177 |
| A | HIS55 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 300 |
| Chain | Residue |
| B | HIS170 |
| G | HIS73 |
| G | GLU77 |
| G | HIS145 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 301 |
| Chain | Residue |
| B | HIS47 |
| B | HIS169 |
| B | GLU173 |
| G | HIS74 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 398 |
| Chain | Residue |
| B | GLN51 |
| B | HIS55 |
| B | LYS177 |
| C | ARG99 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN C 300 |
| Chain | Residue |
| C | HIS170 |
| H | HIS73 |
| H | GLU77 |
| H | HIS145 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN C 301 |
| Chain | Residue |
| C | HIS47 |
| C | HIS169 |
| C | GLU173 |
| H | HIS74 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 398 |
| Chain | Residue |
| C | GLN51 |
| C | HIS55 |
| C | LYS177 |
| D | ARG99 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN D 300 |
| Chain | Residue |
| A | HIS73 |
| A | GLU77 |
| A | HIS145 |
| D | ASP108 |
| D | HIS170 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN D 301 |
| Chain | Residue |
| A | HIS74 |
| D | HIS47 |
| D | HIS169 |
| D | GLU173 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 398 |
| Chain | Residue |
| B | ARG99 |
| D | GLN51 |
| D | HIS55 |
| D | LYS177 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN E 300 |
| Chain | Residue |
| E | HIS170 |
| F | HIS73 |
| F | GLU77 |
| F | HIS145 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN E 301 |
| Chain | Residue |
| E | HIS47 |
| E | HIS169 |
| E | GLU173 |
| F | HIS74 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 398 |
| Chain | Residue |
| E | GLN51 |
| E | HIS55 |
| E | ARG99 |
| E | LYS177 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN F 300 |
| Chain | Residue |
| C | HIS73 |
| C | GLU77 |
| C | HIS145 |
| F | HIS170 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN F 301 |
| Chain | Residue |
| C | HIS74 |
| F | HIS47 |
| F | HIS169 |
| F | GLU173 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 398 |
| Chain | Residue |
| F | GLN51 |
| F | HIS55 |
| F | LYS177 |
| G | ARG99 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN G 300 |
| Chain | Residue |
| D | HIS73 |
| D | GLU77 |
| D | HIS145 |
| G | HIS170 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN G 301 |
| Chain | Residue |
| D | HIS74 |
| G | HIS47 |
| G | HIS169 |
| G | GLU173 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 398 |
| Chain | Residue |
| G | HIS55 |
| G | LYS177 |
| H | ARG99 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN H 300 |
| Chain | Residue |
| E | HIS73 |
| E | GLU77 |
| E | HIS145 |
| H | HIS170 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN H 301 |
| Chain | Residue |
| E | HIS74 |
| H | HIS47 |
| H | HIS169 |
| H | GLU173 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 398 |
| Chain | Residue |
| F | ARG99 |
| H | GLN51 |
| H | HIS55 |
| H | LYS177 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN I 300 |
| Chain | Residue |
| I | HIS170 |
| J | HIS73 |
| J | GLU77 |
| J | HIS145 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN I 301 |
| Chain | Residue |
| I | HIS47 |
| I | HIS169 |
| I | GLU173 |
| J | HIS74 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 I 398 |
| Chain | Residue |
| I | HIS55 |
| I | ARG99 |
| I | LYS177 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN J 300 |
| Chain | Residue |
| J | HIS170 |
| O | HIS73 |
| O | GLU77 |
| O | HIS145 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN J 301 |
| Chain | Residue |
| J | HIS47 |
| J | HIS169 |
| J | GLU173 |
| O | HIS74 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 J 398 |
| Chain | Residue |
| J | HIS55 |
| J | LYS177 |
| K | ARG99 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN K 300 |
| Chain | Residue |
| K | HIS170 |
| P | HIS73 |
| P | GLU77 |
| P | HIS145 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN K 301 |
| Chain | Residue |
| K | HIS47 |
| K | HIS169 |
| K | GLU173 |
| P | HIS74 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 K 398 |
| Chain | Residue |
| K | GLN51 |
| K | HIS55 |
| K | LYS177 |
| L | ARG99 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN L 300 |
| Chain | Residue |
| I | HIS73 |
| I | GLU77 |
| I | HIS145 |
| L | HIS170 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN L 301 |
| Chain | Residue |
| I | HIS74 |
| L | HIS47 |
| L | HIS169 |
| L | GLU173 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 L 398 |
| Chain | Residue |
| J | ARG99 |
| L | GLN51 |
| L | HIS55 |
| L | LYS177 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN M 300 |
| Chain | Residue |
| M | HIS170 |
| N | HIS73 |
| N | GLU77 |
| N | HIS145 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN M 301 |
| Chain | Residue |
| M | HIS47 |
| M | HIS169 |
| M | GLU173 |
| N | HIS74 |
| site_id | EC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 M 398 |
| Chain | Residue |
| M | HIS55 |
| M | ARG99 |
| M | LYS177 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN N 300 |
| Chain | Residue |
| K | HIS73 |
| K | GLU77 |
| K | HIS145 |
| N | HIS170 |
| site_id | EC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN N 301 |
| Chain | Residue |
| K | HIS74 |
| N | HIS47 |
| N | HIS169 |
| N | GLU173 |
| site_id | EC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 N 398 |
| Chain | Residue |
| N | HIS55 |
| N | LYS177 |
| O | ARG99 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN O 300 |
| Chain | Residue |
| L | HIS73 |
| L | GLU77 |
| L | HIS145 |
| O | HIS170 |
| site_id | EC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN O 301 |
| Chain | Residue |
| L | HIS74 |
| O | HIS47 |
| O | HIS169 |
| O | GLU173 |
| site_id | EC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 O 398 |
| Chain | Residue |
| O | GLN51 |
| O | HIS55 |
| O | LYS177 |
| P | ARG99 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN P 300 |
| Chain | Residue |
| M | HIS73 |
| M | GLU77 |
| M | HIS145 |
| P | HIS170 |
| site_id | FC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN P 301 |
| Chain | Residue |
| M | HIS74 |
| P | HIS47 |
| P | HIS169 |
| P | GLU173 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 P 398 |
| Chain | Residue |
| N | ARG99 |
| P | GLN51 |
| P | HIS55 |
| P | LYS177 |
Functional Information from PROSITE/UniProt
| site_id | PS00954 |
| Number of Residues | 14 |
| Details | IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IDdHHtnEdiALAI |
| Chain | Residue | Details |
| A | ILE70-ILE83 |
| site_id | PS00955 |
| Number of Residues | 13 |
| Details | IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GeNsHHiiEAtFK |
| Chain | Residue | Details |
| A | GLY165-LYS177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 368 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O23346","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 128 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16338409","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2F1D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
