2EZ6
Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004525 | molecular_function | ribonuclease III activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006396 | biological_process | RNA processing |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008033 | biological_process | tRNA processing |
| A | 0010468 | biological_process | regulation of gene expression |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003725 | molecular_function | double-stranded RNA binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004525 | molecular_function | ribonuclease III activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006364 | biological_process | rRNA processing |
| B | 0006396 | biological_process | RNA processing |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008033 | biological_process | tRNA processing |
| B | 0010468 | biological_process | regulation of gene expression |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | GLU40 |
| A | ASP107 |
| A | GLU110 |
| A | HOH502 |
| A | HOH503 |
| C | HOH29 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 502 |
| Chain | Residue |
| B | HOH503 |
| D | HOH29 |
| D | HOH30 |
| B | GLU40 |
| B | ASP107 |
| B | GLU110 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 234 |
| Details | Domain: {"description":"RNase III"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 136 |
| Details | Domain: {"description":"DRBM"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15016361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18047582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11738048","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1JFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RC5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
