2EYQ
Crystal structure of Escherichia coli transcription-repair coupling factor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000716 | biological_process | transcription-coupled nucleotide-excision repair, DNA damage recognition |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006283 | biological_process | transcription-coupled nucleotide-excision repair |
| A | 0006294 | biological_process | nucleotide-excision repair, preincision complex assembly |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006974 | biological_process | DNA damage response |
| A | 0015616 | molecular_function | DNA translocase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043175 | molecular_function | RNA polymerase core enzyme binding |
| A | 1990391 | cellular_component | DNA repair complex |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000716 | biological_process | transcription-coupled nucleotide-excision repair, DNA damage recognition |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003684 | molecular_function | damaged DNA binding |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006281 | biological_process | DNA repair |
| B | 0006283 | biological_process | transcription-coupled nucleotide-excision repair |
| B | 0006294 | biological_process | nucleotide-excision repair, preincision complex assembly |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006974 | biological_process | DNA damage response |
| B | 0015616 | molecular_function | DNA translocase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0043175 | molecular_function | RNA polymerase core enzyme binding |
| B | 1990391 | cellular_component | DNA repair complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1149 |
| Chain | Residue |
| A | THR658 |
| A | THR659 |
| A | LEU660 |
| A | ARG685 |
| B | HIS842 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1150 |
| Chain | Residue |
| A | ARG395 |
| A | ARG411 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1149 |
| Chain | Residue |
| B | ARG395 |
| B | ARG411 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EPE B 1150 |
| Chain | Residue |
| A | HIS842 |
| B | THR658 |
| B | THR659 |
| B | LEU660 |
| B | ARG685 |
| B | THR710 |
| B | HIS711 |
| B | LYS712 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EPE A 1151 |
| Chain | Residue |
| A | HIS897 |
| A | ARG900 |
| A | LEU936 |
| A | GLU937 |
| A | ASP938 |
| A | LEU939 |
| A | GLY940 |
| A | ALA941 |
| A | GLY942 |
| A | PHE943 |
| A | HOH1166 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EPE B 1151 |
| Chain | Residue |
| B | HIS897 |
| B | ARG900 |
| B | LEU936 |
| B | GLU937 |
| B | ASP938 |
| B | LEU939 |
| B | GLY940 |
| B | ALA941 |
| B | GLY942 |
| B | PHE943 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EPE A 1152 |
| Chain | Residue |
| A | GLN459 |
| A | ARG462 |
| A | ARG782 |
| A | ARG905 |
| A | SER906 |
| A | HIS907 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EPE B 1152 |
| Chain | Residue |
| B | SER461 |
| B | ARG782 |
| B | ARG905 |
| B | SER906 |
| B | HIS907 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 322 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_00969","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 306 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"HAMAP-Rule","id":"MF_00969","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Motif: {"description":"DEEH box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00969","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
